Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (6): 2175-2187.DOI: 10.6023/cjoc202101044 Previous Articles     Next Articles



杨凯a,b, 刘美娟a, 张毓娜a, 占佳琦a, 邓璐璇a, 郑雪洁a, 周永军a, 汪朝阳a,*()   

  1. a 华南师范大学化学学院 教育部环境理论化学重点实验室 广州市生物医药分析化学重点实验室 广州 510006
    b 赣南医学院药学院 江西赣州 341000
  • 收稿日期:2021-01-26 修回日期:2021-02-20 发布日期:2021-03-04
  • 通讯作者: 汪朝阳
  • 基金资助:
    广州市科技计划科学研究专项(201607010251); 广东省科技计划(2017A010103016); 江西省教育厅科学技术研究(GJJ201504); 赣南医学院(YB201903); 广东省大学生创新创业训练计划(S202010574059)

Progress in the Synthesis of Benzoheterocycles from 2-Halobenzamides

Kai Yanga,b, Meijuan Liua, Yu'na Zhanga, Jiaqi Zhana, Luxuan Denga, Xuejie Zhenga, Yongjun Zhoua, Zhaoyang Wanga()   

  1. a Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006
    b College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000
  • Received:2021-01-26 Revised:2021-02-20 Published:2021-03-04
  • Contact: Zhaoyang Wang
  • Supported by:
    Guangzhou Science and Technology Project Scientific Special(201607010251); Guangdong Provincial Science and Technology Project(2017A010103016); Scientific Research Fund of Jiangxi Provincial Education Department(GJJ201504); Gannan Medical University(YB201903); Undergraduates Innovation Project of Guangdong Province(S202010574059)

Owing to important pharmacological and biological activities of benzoheterocyclic compounds, their exploration for efficient synthesis methods in drug field is of great value and wide application. Due to the existence of multiple functional groups and reaction sites, great progress has been made in the synthesis of quinazolinones, isoquinolinones, isoindolinones, benzisothiazolones and other benzoheterocyclic compounds using 2-halobenzamides as important synthons. In view of this, according to the different structures of the products, the research progress in the synthesis of benzoheterocyclic compounds with 2-halobenzamides as the starting material in recent 10 years is summarized, and the related reaction mechanism is expounded.

Key words: 2-halobenzamide, metal catalysis, domino reaction, cyclization reaction, benzoheterocyclic compound, reaction mechanism