Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (1): 156-170.DOI: 10.6023/cjoc202205034 Previous Articles     Next Articles



袁成, 潘长多*()   

  1. 江苏理工学院化学化工学院 江苏常州 213001
  • 收稿日期:2022-05-20 修回日期:2022-06-29 发布日期:2022-08-10
  • 通讯作者: 潘长多

Recent Advances in the N-Aryl C—H Functionalization Using 7-Azaindole as Intrinsic Directing Group

Cheng Yuan, Changduo Pan()   

  1. School of Chemistry and Chemical Engineering, Jiangsu University of Technology, Changzhou, Jiangsu 213001
  • Received:2022-05-20 Revised:2022-06-29 Published:2022-08-10
  • Contact: Changduo Pan

The intrinsic directing group is a functional group in the substrates and also serves as an essential component in products. Thus, the preinstallation and removal of directing groups are avoided. 7-Azaindole has been used as intrinsic directing group for the N-aryl-C—H functionalization of N-aryls under the catalysis of transition metals. Utilizing the C—H functionalization strategy, numerous functional groups were installed into the ortho-position of N-aryls of the corresponding N-aryl-7-azaindoles. In this review, the recent achievements on the transition-metal catalyzed N-aryl ortho-C—H functionalization directed by 7-azaindole are summarized.

Key words: 7-azaindole, intrinsic directing group, C—H activation, transition-metal catalyzed