Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (8): 2711-2719.DOI: 10.6023/cjoc202303009 Previous Articles     Next Articles


陈新强, 张敬*()   

  1. 武汉大学高等研究院 武汉 430000
  • 收稿日期:2023-03-04 修回日期:2023-04-04 发布日期:2023-04-13
  • 基金资助:
    国家自然科学基金(22071185); 国家自然科学基金(22271224); 中央高校基本科研业务费专项资金(2042019kf0008); 武汉大学启动基金资助项目

Progress in the Study of Dehydroxymethylation of Primary Alcohol

Xinqiang Chen, Jing Zhang()   

  1. The Institute for Advanced Studies, Wuhan University, Wuhan 430000
  • Received:2023-03-04 Revised:2023-04-04 Published:2023-04-13
  • Contact: *E-mail:
  • Supported by:
    The National Natural Science Foundation of China(22071185); The National Natural Science Foundation of China(22271224); The Fundamental Research Funds for the Central Universities(2042019kf0008); The Wuhan University Startup Funding

Primary alcohols are abundant and readily available, which have been widely used as feedstock chemicals for the synthesis of agrochemicals, food additives, fragrances, pharmaceuticals and so on. The dehydroxymethylation reaction is an effective strategy to prepare hydrocarbons with one less carbon atom from primary alcohols, which has attracted tremendous attentions of many organic chemists and applied in biomass degradation and drug synthesis. The development of dehydroxy- methylation of primary alcohol on the base of the reaction characters is reviewed, including transition-metal catalyzed dehydroxymethylation to access methane and water, transition-metal catalyzed dehydroxymethylation to produce carbon monoxide and hydrogen, transition-metal catalyzed dehydroxymethylation to generate formaldehyde, as well as transition-metal free dehydroxymethylation to furnish formic acid and water. Each type of reaction is systematically summarized according to the catalytic system, the substrates scope and reaction mechanism.

Key words: primary alcohol, dehydroxymethylation, transition-metal catalyzed, hydrocarbon