Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (4): 1363-1367.DOI: 10.6023/cjoc202309005 Previous Articles     Next Articles

土坛树中高度氧化的杜松烷型倍半萜及其生物活性研究

魏艳梅a,b, 余章昕a,b, 杜怡益a,b, 王平淑a,b, 岑福凌a,b, 李小宝a,b, 陈光英a,b,*()   

  1. a 海南师范大学 热带药用资源化学教育部重点实验室 海口 571158
    b 海南师范大学化学与化工学院 海南省热带药用植物化学重点实验室 海口 571158
  • 收稿日期:2023-09-04 修回日期:2023-10-31 发布日期:2023-11-15
  • 作者简介:† 共同第一作者.
  • 基金资助:
    海南省重点研发项目(ZDYF2022SHFZ286); 海南省重点研发项目(ZDYF2021SHFZ072); 国家自然科学基金(21662012); 海南省院士创新平台(YSPTZX202030); 中央引导地方科技发展专项(ZY2022HN08); 海南师范大学“大学生创新创业训练计划”(202311658005)

Studies on the Highly Oxidized Cadinane Sesquiterpenes from Alangium salviifolium and Their Bioactivities

Yanmei Weia,b, Zhangxin Yua,b, Yiyi Dua,b, Pingshu Wanga,b, Fuling Cena,b, Xiaobao Lia,b, Guangying Chena,b()   

  1. a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158
    b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
  • Received:2023-09-04 Revised:2023-10-31 Published:2023-11-15
  • Contact: E-mail: chgying123@163.com
  • About author:† The authors contributed equally to this work.
  • Supported by:
    Key R&D Projects in Hainan Province-Social Development(ZDYF2022SHFZ286); Key R&D Projects in Hainan Province-Social Development(ZDYF2021SHFZ072); National Natural Science Foundation of China(21662012); Innovation Platform for Academicians of Hainan Province(YSPTZX202030); Central Government Guides Local Science and Technology Development(ZY2022HN08); Hainan Normal University “Innovative Entrepreneurship Training Program for College Students”(202311658005)

Two new highly oxidized cadinane sesquiterpenes of alansalene A (1) and 2,7-dihydroxy-4-isopropyl-1-methyl- 6-naphthaldehyde (5), and five known analogues were isolated from the barks of Alangium salviifolium, which is a folk medicinal plant in Hainan. The structures were elucidated by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Compound alangene D (2) exhibited stronger anti-inflammatory activity in vitro with IC50 value of (2.98±0.11) μmol/L to that of dexamethasone [IC50=(39.62±0.12) μmol/L]. Alangene F (3) and 2,7-dihydroxy-4-isopropyl-6-methylnaphthalene-1- carbaldehyde (6) displayed potential α-glucosidase inhibitory activities with IC50 values of (111.85±1.80) and (18.55±0.68) μmol/L, respectively, which were stronger than that of acarbose [IC50=(478.75±27.14) μmol/L].

Key words: Alangium salviifolium, highly oxidization, sesquiterpene, anti-inflammatory, α-glucosidase inhibitory