Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (3): 748-779.DOI: 10.6023/cjoc202311004 Previous Articles     Next Articles



陈远航, 何劲宇, 张博, 王延钊, 孔令轩, 钱伟烽, 王娜娜, 段闻喜, 欧阳妍妍, 朱翠菊*(), 徐浩*()   

  1. 华中师范大学化学学院 武汉 430079
  • 收稿日期:2023-11-03 修回日期:2024-01-23 发布日期:2024-04-02
  • 作者简介:共同第一作者
  • 基金资助:
    国家自然科学基金(21801087); 国家自然科学基金(22201089); 华中师范大学基础研究基金(CCNU19QN064)

Asymmetric Electrochemical Organic Synthesis

Yuanhang Chen, Jinyu He, Bo Zhang, Yanzhao Wang, Lingxuan Kong, Weifeng Qian, Na'na Wang, Wenxi Duan, Yanyan Ouyang, Cuiju Zhu(), Hao Xu()   

  1. College of Chemistry, Central China Normal University, Wuhan 430079
  • Received:2023-11-03 Revised:2024-01-23 Published:2024-04-02
  • Contact: *E-mail:;
  • About author:These authors contributed equally to this work.
  • Supported by:
    National Natural Science Foundation of China(21801087); National Natural Science Foundation of China(22201089); Fundamental Research Funds for the Central Universities of Central China Normal University(CCNU19QN064)

Organic electrosynthesis can be traced back to the 19th century. The development of electroorganic synthesis has a long history. The combination of asymmetric catalysis and organic electrosynthesis opens up a new avenue for asymmetric organic synthesis. Thus, it has gradually emerged as a crucial approach for chiral compounds synthesis in recent years. Therefore, asymmetric electrosynthesis has garnered major attention of many organic synthetic researchers, and achieved considerable advances. Asymmetric electrosynthesis can transcend the limitations of traditional synthesis, controlling selectivity of the reaction through current and voltage adjustments. Moreover electrochemical synthesis is a novel sustainable methodology by replaced toxic and costly chemicals with renewable electricity. At present, asymmetric electrochemistry has been combined with organocatalysis, metal catalysis, photocatalysis, enzyme catalysis and other fields, showcasing significant potential in the synthesis of drug molecules. However, the asymmetric electrochemistry still presents several challenges to control the chemo-, regio-, and enantioselectivities. In this review, the breakthroughs and advances of asymmetric electrochemistry in the past 20 years are summarized. This overview of the field is organized by reaction types: metal reduction catalysis, metal oxidation catalysis, organic reduction catalysis and organic oxidation catalysis.

Key words: electrochemistry, asymmetric synthesis, asymmetric electrochemistry, metal catalysis, organocatalysis