Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (6): 1949-1956.DOI: 10.6023/cjoc202311023 Previous Articles Next Articles
ARTICLES
梁国超a, 董婷婷a, 纪海莹a, 王春艳a, 宋亚丽b, 张伟a,*()
收稿日期:
2023-11-23
修回日期:
2024-01-18
发布日期:
2024-03-05
基金资助:
Guochao Lianga, Tingting Donga, Haiying Jia, Chunyan Wanga, Yali Songb, Wei Zhanga,*()
Received:
2023-11-23
Revised:
2024-01-18
Published:
2024-03-05
Contact:
* E-mail: Supported by:
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Guochao Liang, Tingting Dong, Haiying Ji, Chunyan Wang, Yali Song, Wei Zhang. Synthesis and Antitumor Activity of Novel 3,3'-((4-Chloro-2H-thiochromen-3-yl)methylene)bis(1H-indole)-Like Topoisomerase II Inhibitors[J]. Chinese Journal of Organic Chemistry, 2024, 44(6): 1949-1956.
Compd. | IC50/(μmol•L–1) | |||||
---|---|---|---|---|---|---|
HeLa | H446 | U-937 | MCF-7 | SK-OV-3 | HT-29 | |
5a | 16.5±1.2 | 17.6±3.2 | 12.7±1.1 | 17.7±2.8 | 18.6±2.1 | 19.8±1.9 |
5b | 14.5±2.2 | 8.6±1.4 | 10.3±1.9 | 14.2±1.7 | 16.8±1.9 | 14.1±3.4 |
5c | 22.4±2.7 | 18.8±2.0 | 11.9±2.4 | 10.5±2.2 | 15.4±1.6 | 12.2±2.3 |
5d | 38.4±3.3 | 65.6±3.6 | 72.7±4.1 | 47.5±2.5 | 66.6±2.4 | 72.6±3.9 |
5e | 20.5±1.5 | 28.9±1.4 | 21.4±2.1 | 65.1±4.2 | 41.5±2.7 | 25.3±3.2 |
5f | 8.7±1.2 | 8.8±2.1 | 14.3±3.1 | 14.9±1.7 | 13.3±2.7 | 21.1±1.6 |
5g | 10.6±2.3 | 12.8±1.4 | 10.5±1.7 | 7.4±1.8 | 14.7±3.6 | 12.7±2.3 |
5h | 66.7±2.6 | 32.5±1.7 | 45.7±4.5 | 34.6±2.2 | 64.3±3.9 | 22.6±2.4 |
5i | 45.2±3.6 | 37.8±3.1 | 35.2±2.8 | 29.5±3.3 | 56.2±4.2 | 36.6±3.6 |
5j | 65.7±2.9 | 50.4±3.6 | 45.8±5.5 | 63.4±4.6 | 45.6±4.5 | 67.2±4.4 |
5k | 36.4±6.3 | 62.1±6.4 | 76.8±4.8 | 68.4±2.2 | 45.7±3.1 | 53.1±3.7 |
5l | 19.6±2.3 | 20.6±1.9 | 35.7±3.4 | 58.2±4.6 | 64.2±2.9 | 60.7±3.6 |
5m | 72.5±4.3 | 48.4±3.4 | 32.4±2.1 | 54.0±5.2 | 62.4±3.2 | 43.2±4.2 |
VP-16 | 8.6±1.4 | 9.1±0.4 | 8.2±1.5 | 8.4±0.6 | 9.8±1.5 | 7.2±1.1 |
CPT | 7.4±1.5 | 8.7±1.3 | 10.4±1.5 | 7.8±1.4 | 8.5±1.2 | 7.7±1.2 |
Compd. | IC50/(μmol•L–1) | |||||
---|---|---|---|---|---|---|
HeLa | H446 | U-937 | MCF-7 | SK-OV-3 | HT-29 | |
5a | 16.5±1.2 | 17.6±3.2 | 12.7±1.1 | 17.7±2.8 | 18.6±2.1 | 19.8±1.9 |
5b | 14.5±2.2 | 8.6±1.4 | 10.3±1.9 | 14.2±1.7 | 16.8±1.9 | 14.1±3.4 |
5c | 22.4±2.7 | 18.8±2.0 | 11.9±2.4 | 10.5±2.2 | 15.4±1.6 | 12.2±2.3 |
5d | 38.4±3.3 | 65.6±3.6 | 72.7±4.1 | 47.5±2.5 | 66.6±2.4 | 72.6±3.9 |
5e | 20.5±1.5 | 28.9±1.4 | 21.4±2.1 | 65.1±4.2 | 41.5±2.7 | 25.3±3.2 |
5f | 8.7±1.2 | 8.8±2.1 | 14.3±3.1 | 14.9±1.7 | 13.3±2.7 | 21.1±1.6 |
5g | 10.6±2.3 | 12.8±1.4 | 10.5±1.7 | 7.4±1.8 | 14.7±3.6 | 12.7±2.3 |
5h | 66.7±2.6 | 32.5±1.7 | 45.7±4.5 | 34.6±2.2 | 64.3±3.9 | 22.6±2.4 |
5i | 45.2±3.6 | 37.8±3.1 | 35.2±2.8 | 29.5±3.3 | 56.2±4.2 | 36.6±3.6 |
5j | 65.7±2.9 | 50.4±3.6 | 45.8±5.5 | 63.4±4.6 | 45.6±4.5 | 67.2±4.4 |
5k | 36.4±6.3 | 62.1±6.4 | 76.8±4.8 | 68.4±2.2 | 45.7±3.1 | 53.1±3.7 |
5l | 19.6±2.3 | 20.6±1.9 | 35.7±3.4 | 58.2±4.6 | 64.2±2.9 | 60.7±3.6 |
5m | 72.5±4.3 | 48.4±3.4 | 32.4±2.1 | 54.0±5.2 | 62.4±3.2 | 43.2±4.2 |
VP-16 | 8.6±1.4 | 9.1±0.4 | 8.2±1.5 | 8.4±0.6 | 9.8±1.5 | 7.2±1.1 |
CPT | 7.4±1.5 | 8.7±1.3 | 10.4±1.5 | 7.8±1.4 | 8.5±1.2 | 7.7±1.2 |
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