Two New Linear Furocoumarins from Notopterygium incisum and Their Anti-inflammatory Activity

doi:10.6023/cjoc202505002

Chinese Journal of Organic Chemistry ›› 2026, Vol. 46 ›› Issue (1): 300-303.DOI: 10.6023/cjoc202505002 Previous Articles Next Articles

羌活中两个新的线型呋喃香豆素类成分及其抗炎活性

胡苏^a, 赵丽莲^a^,^b, 李昕宇^a, 叶雨蓓^c, 邓赟^a, 黄莉钧^b^,^*(), 郭大乐^a^,^*()

^a 成都中医药大学药学院成都 611137
^b 成都中医药大学基础医学院成都 611137
^c 成都中医药大学临床医学院成都 611137

收稿日期:2025-06-20 修回日期:2025-07-15 发布日期:2025-08-26
通讯作者: 黄莉钧, 郭大乐
基金资助:
国家自然科学基金(82304887); 四川省科技计划(2024ZYD0116)

Two New Linear Furocoumarins from Notopterygium incisum and Their Anti-inflammatory Activity

Hu Su^a, Zhao Lilian^a^,^b, Li Xinyu^a, Ye Yubei^c, Deng Yun^a, Huang Lijun^b^,^*(), Guo Dale^a^,^*()

^a School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137
^b School of Basic Medical Science, Chengdu University of Traditional Chinese Medicine, Chengdu 611137
^c School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137

Received:2025-06-20 Revised:2025-07-15 Published:2025-08-26
Contact: Huang Lijun, Guo Dale
Supported by:
National Natural Science Foundation of China(82304887); Sichuan Science and Technology Program(2024ZYD0116)

1. .pdf(4464KB)

Abstract

Two new linear furocoumarins were isolated from Notopterygium incisum using silica gel, gel Sephadex LH-20 column chromatography, and preparative high-performance liquid chromatography. The structures of the new compounds were elucidated through analysis of spectroscopic evidence, including data obtained from high-resolution electrospray ionization mass spectrometry (HRESIMS) and nuclear magnetic resonance (NMR). The absolute configurations of Notoprenylate L (1) and Nototerprinol K (2) were further confirmed using electronic circular dichroism (ECD) calculations. Compound 1 demonstrated the ability to inhibit the expression of nitric oxide (NO), a pro-inflammatory factor, in lipopolysaccharide-induced RAW264.7 macrophages at a concentration of 7.5 μmol/L, indicating its potential for anti-inflammatory activity.

Key words: Notopterygium incisum, linear furocoumarin, anti-inflammatory activity

Cite this article

Hu Su, Zhao Lilian, Li Xinyu, Ye Yubei, Deng Yun, Huang Lijun, Guo Dale. Two New Linear Furocoumarins from Notopterygium incisum and Their Anti-inflammatory Activity[J]. Chinese Journal of Organic Chemistry, 2026, 46(1): 300-303.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

share this article

Fig. & Tab. 3

References 13

[1]	Azietaku J. T.; Ma H.; Yu X. A.; Li J.; Oppong M. B.; Cao J.; Chang Y. X. J. Ethnopharmacol. 2017, 202, 241.
[2]	Tang Z.; Zheng R.; Chen P.; Li L. Molecules 2024, 29, 3252.
[3]	Hu Y. J.; Liu M. D.; Mu Y. T.; Li C. C.; Zhao M. H.; Guo D. L.; Deng Y. Chem. Biodiversity 2024, 21, e202401093.
[4]	Huo X. Y.; Liu M. D.; Chen Y. H.; Hu Y. J.; Yan C. Y.; Guo D. L.; Deng Y. J. Asian Nat. Prod. Res. 2025, 27, 18.
[5]	Ma L. M.; Chai T.; Wang C. B.; Zheng Y. D.; Ma L.; Meng X. H.; Yang J. L. Phytochem. Lett. 2022, 49, 138.
[6]	Bi J. P.; Li P.; Xu X. X.; Wang T.; Li F. Chin. J. Nat. Med. 2018, 16, 926 (in Chinese).
	(毕建平, 李平, 徐习习, 王婷, 李飞, 中国天然药物, 2018, 16, 926.)
[7]	Wu S. B.; Pang F.; Wen Y.; Zhang H. F.; Zhao Z.; Hu J. F. Planta Med. 2010, 76, 82.
[8]	Zheng X.; Zheng X.; Zhang C.; Zhang Q.; Jiang Y.; Tu P. Chin. Chem. Lett. 2019, 30, 428.
[9]	Zhou X.; Niu Z.; Wu H.; Chen B.; Li J.; Qi L.; Shen T. Ind. Crops Prod. 2025, 229, 120944.
[10]	Ye M.; Feng Q.; Jiang Y.; Wang F.; Shi X.; Yang X.; Liu W. Mol. Nutr. Food Res. 2023, 67, 2200713.
[11]	Zheng X.; Wen R.; Liu Y.; Gan L.; Zhang Q.; Jiang Y.; Tu P. Bioorg. Chem. 2022, 128, 106060.
[12]	Ghasemi S.; Habibi Z. Nat. Prod. Res. 2014, 28, 1808.
[13]	Du H. F.; Li L.; Zhang Y. H.; Wang X.; Zhou C. Y.; Zhu H. J.; Pittman C. U.; Shou J. W.; Cao F. Mar. Life Sci. Technol. 2025, 7, 120.

羌活中两个新的线型呋喃香豆素类成分及其抗炎活性

Two New Linear Furocoumarins from Notopterygium incisum and Their Anti-inflammatory Activity

RichHTML

PDF

Supporting Info.

Knowledge

Abstract

Cite this article

share this article

Fig. & Tab. 3

References 13

Related Articles 13

Recommended Articles

Metrics

Comments

[1]	Xiong Qiu, Huijuan Li, Yanling Tang, Yaojun Xu, Na Li, Xiaoli Li, Xingjie Zhang, Weilie Xiao. One New Guaianolide Sesquiterpenoid with Potential Anti-inflammatory Activity from Ainsliaea glabra. [J]. Chinese Journal of Organic Chemistry, 2025, 45(8): 3028-3032.
[2]	Jingjing Zhang, Huiqiong Li, Xingjie Zhang, Yongpeng Wang, Xuemei Zhou, Weilie Xiao, Lijun Cheng, Xiaoli Li. A New Steroid from Armillaria gallica [J]. Chinese Journal of Organic Chemistry, 2025, 45(4): 1411-1416.
[3]	Mengjia Xiao, Xike Gao. Design, Synthesis and Anti-inflammatory Activity of Azulene Derivatives Containing Benzimidazole Unit [J]. Chinese Journal of Organic Chemistry, 2023, 43(9): 3246-3256.
[4]	Zeren Sun, Bingxin Zhai, Guangchao He, Hui Shen, Linya Chen, Shan Zhang, Yi Zou, Qihua Zhu, Yungen Xu. Synthesis and Anti-inflammatory Evaluation of Novel 1,2,3-Triazole Derivatives [J]. Chinese Journal of Organic Chemistry, 2023, 43(6): 2143-2155.
[5]	Minxin Li, Qiuping Zou, Wenrong Du, Jinchun Gao, Yanping Li, Zewei Mao. Total Synthesis and Anti-inflammatory Evaluation of Dorsmerunin A [J]. Chinese Journal of Organic Chemistry, 2021, 41(8): 3292-3296.
[6]	Li Jun, Xu Xiaoshi, Teng Haida, Chen Yu, Mei Zhinan, Yang Guangzhong. Chemical Constituents from Hypericum Erectum Thunb [J]. Chinese Journal of Organic Chemistry, 2019, 39(12): 3583-3587.
[7]	Mao Zewei, Liu Bei, Zhu Ping, Zhang Lijun, Zhu Jiahong, Wu Linze, Wan Chunping. Synthesis and Biological Evaluation of Piperazine Substituted 3-Aryl-5-furanyldihydropyrazole Amide Derivatives [J]. Chin. J. Org. Chem., 2018, 38(8): 2167-2173.
[8]	Gao Hui, Zheng Xi, Zhu Ping, Wang Si, Wan Chunping, Rao Gaoxiong, Mao Zewei. Synthesis and Biological Evaluation of Novel Substituted Chalcone-piperazine Derivatives [J]. Chin. J. Org. Chem., 2018, 38(3): 684-691.
[9]	Rui Jian, Yang Jianlai, Huang Jianfeng, Wang Jiayu, Xu Xua, Xu Haijun, Wang Shifa. Synthesis, Antitumor and Anti-inflammatory Activities of Isolongifolanonyl Pyrazole Derivatives [J]. Chin. J. Org. Chem., 2016, 36(9): 2183-2190.
[10]	Sun Nan, Wang Xing, Ding Zhibing, Zhang Qi, Xu Xu, Xu Haijun, Wang Shifa. Synthesis and Biological Activity of Novel Pinanyl Thiazole Derivatives [J]. Chin. J. Org. Chem., 2016, 36(10): 2489-2495.
[11]	YANG Ding-Ju, LI Ying, YIN Shu-Fan*. Synthesis and Anti-inflammatory Activity of 3-Acetyl-2-[(un)substituted phenyl]-2,3-dihydro-1,3,4-oxadiazol-5-methyl 3-O-Acetylursolate [J]. Chin. J. Org. Chem., 2008, 28(06): 1055-1060.
[12]	FANG Lei^a,HUANG Zhang-Jian^a,ZHANG Yi-Hua*^,a,JI Hui^b,DING Da-Yong^b. Synthesis, Anti-inflammatory Activity and Safety of Hydrocortisone Derivatives Coupled with Furoxans and Nitrates [J]. Chin. J. Org. Chem., 2008, 28(05): 841-850.
[13]	LAI Yi-Sheng*^,a, ZHANG Yi-Hua^a, LI Yue-Zhen^b, JI Hui^c YANG Ming^c, CONG Ri-Gang^a. Synthesis and Biological Activity of 5-Chloro-3-(hydroxy- p-methanesulfonylphenylmethylene)-2-oxo-2,3-dihydroindole-1-carboxamides [J]. Chin. J. Org. Chem., 2007, 27(06): 733-738.