Silver-Catalyzed Decarboxylative C-H Alkylation of Cyclic Aldimines with Monoalkyl Oxalates

doi:10.6023/cjoc202510026

Abstract

Silver-catalyzed decarboxylative Csp²-H alkylation of cyclic aldimines with monoalkyl oxalates via C-O bond cleavage has been realized under mild reaction conditions. The corresponding products were generated in moderate to good yields (30-80%) with wide substrate scope. In addition, late-stage modification of bioactive molecules, and further application of the catalytic strategy were also performed. The mechanistic studies show that the reaction undergoes a radical pathway.

Key words: Silver catalysis, C-H Alkylation, Cyclic aldimines, Monoalkyl oxalates, C-O Bond cleavage

Cite this article

Wang Jingjing, Yu Zihan, Yue Kaihua, Yi Maocong, Zhang Andong,ding Tonghui, Wang Cuijie,cui Mingyue, Liao Kechao, Li Feng. Silver-Catalyzed Decarboxylative C-H Alkylation of Cyclic Aldimines with Monoalkyl Oxalates[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202510026.

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