Visible-Light-Catalyzed Hydroamination, Hydroamidation and Hydrosulfonamidation of Alkenes

doi:10.6023/cjoc202511015

Chinese Journal of Organic Chemistry

REVIEW

可见光催化烯烃的氢胺化和氢(磺)酰胺化反应

张皓然^a,b, 贾均松^a, 俞琼^b, 吴宇^a, 李玉龙^*,a, 舒伟^*,b

^a四川轻化工大学化学与环境工程学院、绿色催化四川省高校重点实验室,四川自贡 643000;
^b南方科技大学深圳市格拉布斯研究院、化学系、广东省催化重点实验室,广东深圳 518055

收稿日期:2025-11-24 修回日期:2026-01-02
基金资助:
国家自然学科基金(No. 22371115, 22171127, 22373056, 22401139, 22501125, 22501190), 四川省自然科学基金(2025ZNSFSC0128)资助项目.

Visible-Light-Catalyzed Hydroamination, Hydroamidation and Hydrosulfonamidation of Alkenes

Zhang Haoran^a,b, Jia Jun-Song^a, Yu Qiong^b, Wu Yu^a, Li Yulong^*,a, Shu Wei^*,b

^aCollege of Chemistry and Environmental Engineering, Key Laborotory of Green Chemistry of Sichuan Instituttes of Higher Education, SichuanUniversity of Science and Engineering, Zigong 643000, Sichuan;
^bShenzhen Grubbs Institute, Department of Chemistry and Guangdong Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, Guangdong

Received:2025-11-24 Revised:2026-01-02
Contact: ^*E-mail: shuw@sustech.edu.cn; yu_longli@suse.edu.cn
Supported by:
NSFC (No. 22371115, 22171127, 22373056, 22501125, 22501190), Natural Science Foundation of Sichuan Province (2025ZNSFSC0128).

N-alkylamines, amides, and sulfonamides, a class of important nitrogen-containing structural units, are ubiquitous in pharmaceutical molecules, agrochemicals, and functional materials. To this end, the efficient and precise synthesis of such substructures is of great significance for molecular design and late-stage modification. Among various synthetic approaches, C-N bond formation represents one of the key strategies. However, traditional C—N bond formation strategies heavily rely on pre-functionalized substrates under strong oxidative/reductive conditions, or elevated reaction temperature, which often suffer from over-alkylation, competitive side reactions, poor regio- and chemoselectivity, limited compatibility with molecular complexity. Over past years, visible-light-driven hydroamination, hydroamidation, and hydrosulfonamidation of alkenes have achieved efficient synthesis of N-alkylamines, amides, and sulfonamides by direct cross-coupling of simple alkenes with various nitrogen sources under mild conditions through different reaction mechanisms such as single-electron transfer, proton-coupled electron transfer, and hydrogen atom transfer. These reactions utilize alkenes as alkylation reagents, demonstrating excellent step-economy and functional group compatibility. This review summarizes the progress and key reaction pathways in the field of visible-light-catalyzed hydroamination, hydroamidation, and hydrosulfonamidation of alkenes, with an emphasis on selectivity control and scope of different catalytic systems, and provides an outlook on future developments in this area, aiming to offer theoretical and practical guidance for further development and application to target synthesis in related areas.

Key words: alkenes, visible-light-catalysis, hydrofunctionalizations, C—N bond-formation, nitrogen-containing compounds

Cite this article

Zhang Haoran, Jia Jun-Song, Yu Qiong, Wu Yu, Li Yulong, Shu Wei. Visible-Light-Catalyzed Hydroamination, Hydroamidation and Hydrosulfonamidation of Alkenes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202511015.

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可见光催化烯烃的氢胺化和氢(磺)酰胺化反应

Visible-Light-Catalyzed Hydroamination, Hydroamidation and Hydrosulfonamidation of Alkenes

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