Recent Advances in Dicarbofunctionalization of Alkynes via Photoredox Catalysis

doi:10.6023/cjoc202512019

Abstract

Photoredox-catalyzed dicarbofunctionalization of alkynes has emerged as a cutting-edge research direction in organic synthesis. This strategy ingeniously integrates the mild activation capabilities of photochemistry with the efficient bond-forming characteristics of transition metal catalysis. Through mechanisms such as single-electron transfer, energy transfer, or proton-coupled electron transfer, highly selective dicarbofunctionalization of alkynes can be achieved under visible light conditions. Compared with traditional methods, this approach not only offers mild reaction conditions and excellent functional group tolerance, but also enables precise control over chemo-, regio-, and stereoselectivity, thereby providing a new paradigm for the efficient synthesis of polysubstituted alkenes, cyclic compounds, and bioactive molecules. This review systematically summarizes the latest advances in this field, with a focus on the substrate scope, reaction mechanisms, strategies for selectivity control, and synthetic applications, while also offering perspectives on future development trends.

Key words: Photoredox Catalysis, Transition Metal Catalysis, Alkynes, Regioselectivity, Dicarbofunctionalization

Cite this article

Ye Fu, Yuan Weiming. Recent Advances in Dicarbofunctionalization of Alkynes via Photoredox Catalysis[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202512019.

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