Recent Advances in the Structural Modifications and Applications of Ribavirin

doi:10.6023/cjoc202601025

Abstract

Structural modification of nucleoside analogues is an important strategy for developing novel drugs. Ribavirin, as one of the representative nucleoside analogues, is a broad-spectrum antiviral nucleoside drug. However, its prolonged or excessive use can lead to side effects, such as reduction in white blood cell count and inhibition of red blood cell production. Therefore, extensive research has focused on developing ribavirin derivatives with improved efficacy and reduced toxicity. This minireview systematically summarizes the structural modifications and applications of ribavirin, primarily including: 1) glycosyl modifications and 2) base modifications. Additionally, novel synthetic methods and potential applications in drug development are discussed, providing insights for the development of novel antiviral drugs.

Key words: Ribavirin, Structural Modification, Application, Glycosyl Modification, Base Modification

Cite this article

Lv Jie, Li Tingting. Recent Advances in the Structural Modifications and Applications of Ribavirin[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202601025.

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