Chinese Journal of Organic Chemistry 2026, 46(8)

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  A novel electrochemical reductive coupling strategy without the need for exogenous redox reagents and catalysts has been successfully developed by Liu, Chen, Meng, Wang, and Tang on page 3246. Under mild reaction conditions, the authors employed naphthalene as the mediator to generate phenyl radicals via cathodic reductive dehalogenation of aryl halides, followed by radical addition with styrene. Starting from readily available multi-type aryl halides (including iodo, bromo and chloro derivatives) and styrene, a series of bibenzyl compounds were efficiently synthesized.
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  A palladium-catalyzed intramolecular Heck/amination reaction of unactivated alkenes, reported by Lin, Zhou, Qin, Song, Song, Gao, Bao, Li, Jiang, and Liu on page 3139, was developed for the construction of a series of spiroindolines in moderate to good yields. In addition, preliminary attempts toward an asymmetric version of this reaction have also been conducted, providing optically active spiroindolines in up to 85% yield and 65% ee which stands for novel chiral skeletons with potential applications in asymmetric catalysis.
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  This review highlights recent advances in the selective oxidation of ethylene glycol to glycolic acid via four green catalytic strategies: thermocatalysis, photocatal-ysis, electrocatalysis, and enzymatic catalysis. The catalytic characteristics, representative achievements, and future prospects of these approaches are system-atically discussed by Wu, Wu, Zhang, Gao, Wang, and Chang on page 2969, providing insights for the de-velopment of efficient and sustainable pathways for polyethylene terephthalate upcycling.
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  A method for the synthesis of Mpro inhibitory com-pounds via reductive alkylation of diketones with aldehydes was reported by Ao, Ma, Wang, He, Shang, Zhu, Li, Zhang, Zhang, and Hou on page 3104. The synthetic compounds (t5, t9, and t18) exhibit potent inhibitory activity against coronavirus Mpro and rep-resent promising candidates for the development of anti-coronavirus agents, providing a material basis for further pharmacodynamic evaluations.
2026, 46(8)

25 August 2026
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REVIEWS ARTICLES HIGHLIGHTS

REVIEWS

Recent Advances in Visible-Light-Induced Reactions Involving N-Alkoxypyridinium Salts

Chaoyang Wang, Chao Pi, Xia Mi

Chinese Journal of Organic Chemistry 2026, 46 (8), pp 2859-2891 DOI: 10.6023/cjoc202605015

Abstract( 73) HTML( 2) PDF(1538KB)( 67 )

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Progress on Transition-Metal-Catalyzed Asymmetric Synthesis of Chiral Tertiary Alkyl Ethers via C—O Bond Formation

Haoyu Zheng, Chuan-Ying Li, You-Yun Zhou

Chinese Journal of Organic Chemistry 2026, 46 (8), pp 2892-2925 DOI: 10.6023/cjoc202604011

Abstract( 71) HTML( 2) PDF(1748KB)( 41 )

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Recent Advances in Asymmetric Carbene Catalytic Reactions Mediated by Rhodium and Chiral Phosphoric Acid

Xiaoyu Zhu, Yiming Luo, Man Sun, Wenze Li

Chinese Journal of Organic Chemistry 2026, 46 (8), pp 2926-2948 DOI: 10.6023/cjoc202602018

Abstract( 99) HTML( 1) PDF(1665KB)( 67 )

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Progress in the Asymmetric Synthesis of C(2) Chiral-4-chromanone Derivatives with Bioactivities

Guixia Wang, Mulan Gong, Jinlong Du, Qiming Cheng, Liwen Miao, Xiangfei Kong

Chinese Journal of Organic Chemistry 2026, 46 (8), pp 2949-2968 DOI: 10.6023/cjoc202601039

Abstract( 96) HTML( 1) PDF(3520KB)( 46 )

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Research Progress in the Selective Catalytic Oxidation of Ethylene Glycol to Glycolic Acid

Rui Wu, Zhiquan Wu, Juan Zhang, Wenchao Gao, Yingxiong Wang, Honghong Chang

Chinese Journal of Organic Chemistry 2026, 46 (8), pp 2969-2987 DOI: 10.6023/cjoc202601006

Abstract( 279) HTML( 1) PDF(10689KB)( 58 )

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Recent Advances in Synthetic Methodology of Sulfur(VI) Fluoride Exchange Click Reactions

Dilfiragul Mangnahun, Qichao Zhang, Fang Zhang, Lin He, Zhihua Cai, Guangfen Du

Chinese Journal of Organic Chemistry 2026, 46 (8), pp 2988-3011 DOI: 10.6023/cjoc202512025

Abstract( 148) HTML( 1) PDF(1347KB)( 52 )

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Recent Advances in the Structural Modifications and Applications of Ribavirin

Jie Lv, Tingting Li

Chinese Journal of Organic Chemistry 2026, 46 (8), pp 3012-3024 DOI: 10.6023/cjoc202601025

Abstract( 102) HTML( 0) PDF(753KB)( 32 )

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Research Progress of Heterometallic Complexes with Aluminum-Metal Bonds Based on Nitrogen-Containing Ligands

Xiong Sun, Yu Guan, Haoran Chen

Chinese Journal of Organic Chemistry 2026, 46 (8), pp 3025-3052 DOI: 10.6023/cjoc202601019

Abstract( 116) HTML( 0) PDF(1356KB)( 23 )

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ARTICLES

Precise Synthesis of Multisubstituted Indoles Enabled by Palladium/Norbornene Cooperative Catalysis

Xuepeng Fu, Jianshu Wang, Shuqing Chen, Honggang Cheng, Qianghui Zhou

Chinese Journal of Organic Chemistry 2026, 46 (8), pp 3053-3067 DOI: 10.6023/cjoc202511008

Abstract( 190) HTML( 0) PDF(771KB)( 61 )