Chin. J. Org. Chem. ›› 1991, Vol. 11 ›› Issue (2): 132-142. Previous Articles     Next Articles

形成大环内酰胺方法的进展

白东鲁;卜运新   

  1. 中国科学院上海药物研究所
  • 发布日期:1991-04-25

Recent progress in the formation of macrolactams

BAI DONG;BU YUNXIN   

  • Published:1991-04-25

A review with 50 refs. on recent progress in the formation of macrolactams. A novel approach for the preparation of polyamine macrolactam has been achieved via the intramol. ring opening of the b-lactam ring as a means of introducing an a-aminopropionic acid residue. A metal template-driven extrusion process may be the most promising method for the double activation of seco-amino acid and macrolactamization in the future.c

Key words: MACROCYCLIC COMPOUNDS, RING CLOSURE REACTION, LACTAM, SYNTHESIS METHODS

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