Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (9): 3448-3458.DOI: 10.6023/cjoc202104060 Previous Articles     Next Articles

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一氧化碳参与β-内酰胺化合物合成的研究进展

王鹏a,*(), 杨妲b, 刘欢b   

  1. a 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032
    b 中国石油大学(华东)理学院 化学系 青岛 266580
  • 收稿日期:2021-04-30 修回日期:2021-05-25 发布日期:2021-06-07
  • 通讯作者: 王鹏
  • 基金资助:
    国家自然科学青年基金(21901250); 中国博士后科学面上基金(2019M651625)

Recent Advances on the Synthesis of β-Lactams by Involving Carbon Monoxide

Peng Wanga(), Da Yangb, Huan Liub   

  1. a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
    b Department of Chemistry, College of Science, China University of Petroleum (East China), Qingdao 266580
  • Received:2021-04-30 Revised:2021-05-25 Published:2021-06-07
  • Contact: Peng Wang
  • Supported by:
    National Natural Science Foundation of China: Youth Project(21901250); General Programs of China Postdoctoral Science Foundation(2019M651625)

β-Lactam compounds are antibiotics with high biological activity and high application value. Design and synthesis of β-lactams with high efficiency and high selectivity have always been a hot issue in organic chemistry. Because of the carbonyl group in the ring structure, the carbonylation reaction between substrate and carbon monoxide (CO) has also developed into a new method for synthesis of β-lactams, which can be used to synthesize novel and diverse structures in one step. In this paper, the carbonylation of different substrates with CO to synthesize β-lactams in recent years is reviewed, and the existing problems and future development of this strategy are prospected.

Key words: β-lactams, carbon monoxide, carbonylation, aziridine, ketene