The asym. alkylations of the new chiral imine prepared from 2-aminomethyl-6-methylpyridine with (+)-camphor in the presence of lithium diisopropylamine (LDA) is reported, and alkylated chiral imine intermediates I (R = Et, CHMe2, CH2Ph, CH2CHMe2, cyclohexyl, CH2CH:CH2) were separated and examd, the asym. inductions vary between 6% to 67%. According to the CD spectra of the alkylated products, the configuration of the main isomer of the alkylated procuts is R configuration at C(11) position by comparing the CD sign pattern of I (R = CH2CH:CH2) with that of the compound having known R configuration.

Key words: C13 NMR SPECTROMETRY, PYRIDINE P, LEUCINE, HALOHYDROCARBON, IMINE, PROTON MAGNETIC RESONANCE SPECTROMETRY, ALKYLATION, ACETIC ACID P, CAMPHOR