Studies on synthesis of  6-aryl-3-(3-nitrophenyl/4-nitro-phenyl)-1, 2, 4-triazolo[3,  4-b]-1, 3, 4-thiadiazole derivatives

Chin. J. Org. Chem. ›› 1999, Vol. 19 ›› Issue (2): 195-199. Previous Articles Next Articles

Original Articles

3-间硝基苯基/对硝基苯基-6-芳基-1, 2, 4-三唑并[3, 4-b]-1, 3, 4-噻二唑衍生物的合成

史海健;史好新;王忠义

安徽师范大学化学系.合肥(241000);中国科学技术大学化学系.合肥(230026)

发布日期:1999-04-25

Studies on synthesis of 6-aryl-3-(3-nitrophenyl/4-nitro-phenyl)-1, 2, 4-triazolo[3, 4-b]-1, 3, 4-thiadiazole derivatives

Shi Haijian;Shi Haoxin;Wang Zhongyi

Anhui Normal Univ.Hefei(241000);Univ Sci & Technol China, Dept Chem. Hefei(230026)

Published:1999-04-25

Abstract

Sixteen title compounds have been prepared by the reaction of 4- amino-5-mercapto-3-(3-nitrophenyl/4-nitrophenyl)-1, 2, 4-triazoles with aryl carboxylic acids in the presence of phosphorus oxychloride. The synthetic reaction conditions has been investigated. All the compounds were screened for antimicrobial activity against bacteria Staphylococcus aureus and Escherichia coli. some compounds appeared very strong antibacterial activity.

Key words: PYRRODIAZOLE P, STAPHYLOCOCCIN, ESCHERICHIA COLI, BIOLOGICAL ACTIVITY, THIADIAZOLE P, BACTERIOSTATIC AGENTS, NITROBENZENE P

CLC Number:

O621

Cite this article

Shi Haijian;Shi Haoxin;Wang Zhongyi. Studies on synthesis of 6-aryl-3-(3-nitrophenyl/4-nitro-phenyl)-1, 2, 4-triazolo[3, 4-b]-1, 3, 4-thiadiazole derivatives[J]. Chin. J. Org. Chem., 1999, 19(2): 195-199.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	Mingjia Guang, Shuo Jiang, Baoyu Zhu, Rusong Zhang, Kunpeng Wang, Minghui Wang, Liangzhong Xu. Design, Synthesis and Insecticidal, Acaricidal Activities of Novel Pyrrole-2-carboxylic Acid and Their Derivatives [J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2895-2904.
[2]	Qifan Wang, Yuanquan Zhang, Li Xing, Yuanxiang Zhou, Chenyu Gong, Bangcan He, Nian Zhang, Yongjun Wu, Wei Xue. Design, Synthesis and Biological Activity of Myricetin Derivatives Containing 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazole [J]. Chinese Journal of Organic Chemistry, 2023, 43(4): 1525-1536.
[3]	Can Yong, Yun Li, Tao Bi, Guofeng Chen, Dongxia Zheng, Zhouyu Wang, Yuanyuan Zhang. Research Progress on the Synthesis and Activity of D-Galactose Derived Small Galectin Inhibitors [J]. Chinese Journal of Organic Chemistry, 2022, 42(5): 1307-1325.
[4]	Jie Luo, Yaqian Yan, Haoxin Wang, Yaoyao Li. Discovery of a New Polycyclic Tetramate Macrolactam Clifednamide K [J]. Chinese Journal of Organic Chemistry, 2022, 42(4): 1224-1228.
[5]	Yajun Mao, Xiangmin Shao, Yangjie Li, Ruimei Cao, Yali Feng, Guangyu Zhai. Research Progress on the Synthesis of Quercetin Derivatives [J]. Chinese Journal of Organic Chemistry, 2022, 42(11): 3588-3605.
[6]	Hongliang Xu, Jing Su, Zishi Wang, Chenxin Hou, Pengchong Wu, Yue Xing, Xiangshuai Li, Xiaolei Zhu, Yuncai Lu, Lijian Xu. Synthesis, Design and Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Research of Phenylpyrrole Fungicides [J]. Chinese Journal of Organic Chemistry, 2021, 41(9): 3560-3570.
[7]	Ting Jiang, Hong Pu, Yanwen Duan, Xiaohui Yan, Yong Huang. New Natural Products of Streptomyces Sourced from Deep-Sea, Desert, Volcanic, and Polar Regions from 2009 to 2020 [J]. Chinese Journal of Organic Chemistry, 2021, 41(5): 1804-1820.
[8]	Xiaotian Qin, Junchao Zhang, Yuqing He, Rui Zhang, Hua Cheng, Cheng Chen, Xin Qin. Synthesis and Biological Activities of Coenzyme Q Derivatives Containing (4-Aryloxylaryl)amino Moiety [J]. Chinese Journal of Organic Chemistry, 2021, 41(5): 2045-2054.
[9]	Meng Xu, Shenyuan Gao, Yuanxu Zeng, Anhui Gao, Lixin Gao, Lei Xu, Yubo Zhou, Jianrong Gao, Qing Ye, Jia Li. Synthesis and Evaluation of 3-(Indol-3-yl)-4-(pyrazolo[3,4- c]pyridazin-3-yl)maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors [J]. Chinese Journal of Organic Chemistry, 2021, 41(5): 1991-2000.
[10]	Jun He, Xuemei Tang, Qing Zhou, Feng Peng, Tingting Liu, Liwei Liu, Ming He, Chengwei Xie, Wei Xue. Design, Synthesis and Biological Activities of Myricetin Derivatives Containing Quinazoline Thioether Moiety [J]. Chinese Journal of Organic Chemistry, 2021, 41(2): 708-718.
[11]	Zhenguo Zhang, Xiaoxiao Liu, Xinlong Zong, Yalin Yuan, Shuanglei Liu, Ting Zhang, Zishang Wu, Jingying Yang, Zhenhua Jia. Recent Advance on the Synthesis of 3,3'-Bisindolylmethane Derivatives under Transition-Metal-Free Catalytic Conditions [J]. Chinese Journal of Organic Chemistry, 2021, 41(1): 52-64.
[12]	Liang Wei, Tan Chengxia, Weng Jianquan, Liu Xinghai. Advances on Synthesis and Biological Activities of Mesoionic Compounds [J]. Chinese Journal of Organic Chemistry, 2020, 40(9): 2702-2713.
[13]	Li Qianqian, Wu Zhongmei, Zhang Min, Zhang Yiping, Zhou Yingkai, Deng Hongmei, Song Liping. Synthesis and Preliminary Exploration of Biological Activity of 3-Aryl-4-arylamine Methyl Isoxazoles [J]. Chinese Journal of Organic Chemistry, 2020, 40(7): 2108-2113.
[14]	Yu Youpei, Duan Wengui, Lin Guishan, Kang Guoqiang, Wang Xiaoyu, Lei Fuhou. Synthesis, Biological Activity and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Study of Novel 4-Methyl-1,2,4-triazole-thioethers Containing gem-Dimethylcyclopropane Ring [J]. Chinese Journal of Organic Chemistry, 2020, 40(6): 1647-1657.
[15]	Zhang Junhui, Zhu Yabo, Weng Jianquan, Yu Qian, Yuan Jing, Chen Jie. Synthesis and Biological Activity of Natural Stilbene-Inspired Substituted Styrylthiazole Derivatives [J]. Chinese Journal of Organic Chemistry, 2020, 40(4): 1055-1061.

3-间硝基苯基/对硝基苯基-6-芳基-1, 2, 4-三唑并[3, 4-b]-1, 3, 4-噻二唑衍生物的合成

Studies on synthesis of 6-aryl-3-(3-nitrophenyl/4-nitro-phenyl)-1, 2, 4-triazolo[3, 4-b]-1, 3, 4-thiadiazole derivatives

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

3-间硝基苯基/对硝基苯基-6-芳基-1, 2, 4-三唑并[3, 4-b]-1, 3, 4-噻二唑衍 生物的合成

Studies on synthesis of 6-aryl-3-(3-nitrophenyl/4-nitro-phenyl)-1, 2, 4-triazolo[3, 4-b]-1, 3, 4-thiadiazole derivatives

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

3-间硝基苯基/对硝基苯基-6-芳基-1, 2, 4-三唑并[3, 4-b]-1, 3, 4-噻二唑衍生物的合成