Studies on the anti-tumor constituents from annonaceae  plants in China

Abstract

This review describes the recent works on anti-tumor constituent from Annonaceae plants of China in our laboratory. About 59 new Annonaceous acetogenins, 32 new polyoxygenated cyclohexenes, 12 new styrypyrones and 3 new alkaloids were isolated from 5 Uvaria species, 5 Goniothalamus species, 1 Annona species and 1 species of Saccopetalum. The structure and stereochemistry of new compounds were determined by means of spectral analysis and chemical reactions. Preliminary bioassay tests showed most of the new isolates exhibit significant anti-tumor activities. Howiinol A, an active anti-tumor constituent has been total synthesized.

Key words: CHINA, ANNONACEAE, BIOLOGICAL ACTIVITY, CHINESE DRUGS FOR ANTI-CANCINOMA (T.C.D.), TOTAL SYNTHESIS, CYCLOHEXENE P

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Chen Ruoyun;Yu Dequan. Studies on the anti-tumor constituents from annonaceae plants in China[J]. Chin. J. Org. Chem., 2001, 21(11): 1046-1050.

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中国番荔枝科植物抗癌有效成分研究

Studies on the anti-tumor constituents from annonaceae plants in China

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