Dynamic Combinatorial Chemistry and Its Applications in Drug Design

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (1): 1-6. Previous Articles Next Articles

动态组合化学研究进展及其在药物设计中的应用

刘征骁, 赵卫光, 李正名^*

南开大学元素有机化学国家重点实验室元素有机化学研究所天津 300071

收稿日期:2002-12-24 修回日期:2003-03-19 接受日期:2003-05-20 发布日期:2022-09-21
基金资助:
“863”计划(No. 2001AA235011)和国家自然科学基金(No. 20202003)资助项目.

Dynamic Combinatorial Chemistry and Its Applications in Drug Design

LIU Zheng-Xiao, ZHAO Wei-Guang, LI Zheng-Ming^*

National Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Received:2002-12-24 Revised:2003-03-19 Accepted:2003-05-20 Published:2022-09-21
Contact: *E-mail: zml@nankai.edu.cn

Abstract

Dynamic combinatorial chemistry (DCC) employs the reversible connections of sets of basic components to implement the dynamic diversities. With the addition of the target molecules, the strongest bonded moleculeis formed through the molecule-recognition step and the building-block of thelibrary self-assemble step. From it, chemists can drive the shifts of the libraries. In this review, the basic concepts are introduced, the reversible process reported in recent years is reviewed, and the examples of its applications aregiven.

Key words: dynamic combinatorial chemistry, dynamic reversibleprocess, molecular recognition, drug design

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LIU Zheng-Xiao, ZHAO Wei-Guang, LI Zheng-Ming. Dynamic Combinatorial Chemistry and Its Applications in Drug Design[J]. Chinese Journal of Organic Chemistry, 2004, 24(1): 1-6.

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动态组合化学研究进展及其在药物设计中的应用

Dynamic Combinatorial Chemistry and Its Applications in Drug Design

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