Synthesis and Study on Biological Activity of  2-Hydrazono-1,3-dithiolane Derivatives

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (2): 234-238. Previous Articles Next Articles

2-取代亚肼基-1,3-二硫杂环戊烷类化合物的合成及其生物活性研究

苟绍华^a, 陈洪超^*,a, 方治平^b, 罗娟^a, 王玉良^a

^a四川大学化学学院成都 610041
^b四川大学基础医学与法医学院成都 610041

收稿日期:2003-01-27 修回日期:2003-08-11 接受日期:2003-09-04 发布日期:2022-09-20
基金资助:
四川省科技厅(No. 01SG045-05)资助项目

Synthesis and Study on Biological Activity of 2-Hydrazono-1,3-dithiolane Derivatives

GOU, Shao-Hua^a, CHEN, Hong-Chao^*,a, FANG, Zhi-Ping^b, LUO, Juan^a, WANG, Yu-Liang^a

^aCollege of Chemistry, Sichuan University, Chengdu 610041
^bSchool of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041

Received:2003-01-27 Revised:2003-08-11 Accepted:2003-09-04 Published:2022-09-20
Contact: * E-mail: chchen@wcums.edu.cn

Abstract

Ten heterocyclic compounds containing sulphur (including seven new compounds, 2a～2g) were synthesized andtheir structures were confirmed by elemental analysis, ¹H NMR, IR and MSspectroscopies. The ultrasound was used in these organic syntheses, which was more convenient, easily controlled. And shorter reaction time and higher yields were achieved under ultrasounic irradiation. 2b, 2c, 2e, 2h, 2i and 2j have a good biologicalactivity on escherichia coli (10407), whereas 2b, 2c, 2f also on streptococcus (1123).

Key words: bactericide, 2-hydrazono-1,3-dithiolane, bioactivity, ultrasound

Cite this article

GOU, Shao-Hua, CHEN, Hong-Chao, FANG, Zhi-Ping, LUO, Juan, WANG, Yu-Liang. Synthesis and Study on Biological Activity of 2-Hydrazono-1,3-dithiolane Derivatives[J]. Chinese Journal of Organic Chemistry, 2004, 24(2): 234-238.

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2-取代亚肼基-1,3-二硫杂环戊烷类化合物的合成及其生物活性研究

Synthesis and Study on Biological Activity of 2-Hydrazono-1,3-dithiolane Derivatives

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