Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (6): 637-640. Previous Articles     Next Articles

ZnCl2-KBH4还原苹果酸和天冬氨酸的研究

刘全忠a,b, 龚流柱a, 蒋耀忠*,a   

  1. a中国科学院成都有机化学研究所不对称合成与手性技术四川省重点实验室 成都 610041
    b西华师范大学化学系 南充 637002
  • 收稿日期:2003-07-15 修回日期:2003-10-13 接受日期:2003-12-19 发布日期:2022-09-21
  • 通讯作者: *E-mail: gonglz@cioc.ac.cn

Study on the Reduction of (S)-Malic Acid and (S)-Aspartic Acid by ZnCl2-KBH4

LIU, Quan-Zhonga,b, GONG, Liu-Zhua, JIANG, Yao-Zhong*,a   

  1. a Key Laboratory for Asymmetric Synthesis and Chirotechnology, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041
    b Department of Chemistry, China West Normal University, Nanchong 637002
  • Received:2003-07-15 Revised:2003-10-13 Accepted:2003-12-19 Published:2022-09-21

Lewis acid mediated reduction of (S)-malic anhydride and(S)-aspartic anhydride using potassium borohydride in tetrahydrofuran yielded (S)-3-hydroxy-γ-butyrolactone and (S)-acetylamino-γ-butyrolactone. The process avoided the occurrence of over-reduced products, maintained the optical purities and decreased the cost with the yield being high.

Key words: (S)-3-hydroxy-γ-butyrolactone, reduction, (S)-malic acid anhydride