Recent Developments of Apoptosis Inducer

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (8): 864-871. Previous Articles Next Articles

细胞凋亡诱导剂研究进展

沙磊^a, 赵宝祥^*,a, 谭伟^a, 苗俊英^b

^a山东大学化学与化工学院济南 250100
^b山东大学生命科学学院济南 250100

收稿日期:2003-08-22 修回日期:2003-11-14 接受日期:2003-12-30 发布日期:2022-09-20
通讯作者: * E-mail: bxzhao@sdu.edu.cn
基金资助:
山东省自然科学基金重点(No. Z2002D05)、山东大学跨学科研究基金资助项目.

Recent Developments of Apoptosis Inducer

SHA Lei^a, ZHAO Bao-Xiang^*,a, TAN Wei^a, MIAO Jun-Ying^b

^aSchool of Chemistry and Chemical Engineering, Shandong University, Jinan 250100
^bSchool of Life Science, Shandong University, Jinan 250100

Received:2003-08-22 Revised:2003-11-14 Accepted:2003-12-30 Published:2022-09-20

Abstract

The apoptosis inducers as anticancer reagents have attracted considerable attention, and now some of them have been used in clinic.They are the promising drugs toward cancer treatment. This paper reviews the recent development of apoptosis inducer with an emphasis on their structures and their structure-activity relationship.

Key words: apoptosis, inducer, anticancer reagent, structure, structure-activity relationship

Cite this article

SHA Lei, ZHAO Bao-Xiang, TAN Wei, MIAO Jun-Ying. Recent Developments of Apoptosis Inducer[J]. Chinese Journal of Organic Chemistry, 2004, 24(8): 864-871.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

share this article

References

1 Willie, A. H.; Kerr, J. F. R.; Currie, A. R. Int. Rev.Cytol. 1980, 68, 251.
2 (a) Ashwell, J. D.; Berger, N. A.; Cidlowski, J. A.; Lane, D. P.; Korsmeyer, S. J. Immunol. Today 1994, 15, 147.
(b) Fisher, D. E. Cell 1994, 78, 539.
3 (a) Laster, S. M.; Wood, J. G.; Gooding, L. R. J. Immunol. 1999, 141, 2629.
(b) Nagata, S.; Glostein, P. Science 1995, 267, 1449.
(c) Barry, M. A.; Behnke, C. A. Biochem. Pharmacol. 1990, 40, 2353.
4 Schmitt, C. A.;Lowe, S. W. J. Pahtol. 1999, 187, 127.
5 Ling, Y. H.; Priebe, W.; Perez-Soler, R. Cancer Res.1993, 53, 1845.
6 Martin, S. J.; Cotter, T. G. Cell Tissue Kinet. 1990, 23, 545.
7 Li, J.-L.; Feng, X.; Liu, B.; Yuan, Y.-J. Chin. J. Org. Chem. 2001, 21, 428 (in Chinese).
(李金亮, 冯霞, 刘斌, 元英进, 有机化学, 2001, 21, 428.)
8 Zhang, J.; Li, H.-H.; Du, C.-Q.; Zhao, K.-W.; Zhang, S.-L.; Miao, J.-Y. Chin. J. Curr. Adv. Gen. Surg. 2001, 4, 145 (in Chinese).
(张捷, 李慧惠, 杜青春, 赵克温, 张尚立, 苗俊英, 中国现代普通外科进展, 2001, 4, 145.)
9 Fang, X.-Y.; Sheng, W. Chem. Life 2002,23, 121 (in Chinese).
(方晓阳, 盛伟, 生命的化学, 2003,23, 121～123.)
10 Lee, W.-R.; Shen, S.-C.; Lin, H.-Y.; Hou, W.-C.; Yang, L.-L.; Chen, Y.-C. Biochem. Pharmacol. 2002, 63, 225.
11 Nakatam, K.; Kajimoto, S.; Jo, M. JP 2001247460[Chem. Abstr. 2001, 135, 190405].
12 Kluza, J.; Lansiaux, A.; Wattez, N.; Hildebrand, M.-P.; Léonce, S.; Pierré, A.; Hichman, J. A.; Bailly, C. Biochem. Pharmacol. 2002, 63, 1443.
13 Yang, X.-Y.; Ni, P.-Z.; Lu, T. Prog. Pharm. Sci. 2002, 26, 261 (in Chinese).
(杨新颖, 倪沛洲, 路涛, 药学进展, 2002, 26, 261.)
14 (a) Xu, S.; Xu, S.-P.; Li, L.-M. Acta Pharm. Sin. 2000, 35, 103 (in Chinese).
(徐嵩, 徐世平, 李兰敏, 药学学报, 2000, 35, 103.)
(b) Xu, S.; Xu, S.-P.; Li, L.-M. Acta Pharm. Sin. 2001, 36, 269 (in Chinese).
(徐嵩, 徐世平, 李兰敏, 药学学报, 2001, 36, 269.)
15 Xu, S.; Xu, S.-P.; Li, L.-M. Acta Pharm. Sin. 2002, 37, 113 (in Chinese).
(徐嵩, 徐世平, 李兰敏, 药学学报, 2002, 37, 113.)
16 Nagasawa, H.; Yamashita, M.; Mikamo, N.; Shimamura, M.; Oka, S.;Uto, Y.; Hori, H. Comp. Biochem. Physiol., A 2002, 132, 33.
17 Lin, P.-S.; Ho, K.-C.; Yang, S.-J. Cancer Lett. 1996, 105, 249.
18 Brown, J. M.; Wang, L.-H. Anticancer Drug Des. 1998, 13, 529.
19 Zhang, Z.-H.; Du, X.-Y.; Sviridov, S.; Chopiuk, G. US 20020035251, 2002 [Chem. Abstr. 2002, 136, 263178].
20 Miao, J.-Y.; Zhao, B.-X.; Li, H.-H.; Zhang, S.-L.; Du, C.-Q. Acta Pharmacol. Sin. 2002, 43, 323.
21 (a) Zhao, B.-X.; Wang, D.-W.; Zuo, H.; Qian, G.-T.; Miao, J.-Y. Chin. J. Org. Chem. 2003, 23, 1026 (inChinese).
(赵宝祥, 王大威, 左华, 钱广桃, 苗俊英, 有机化学, 2003, 23, 1026.)
(b) Zhao, B. X.; Miao, J. Y. Vasc. Pharmacol. 2003, 40, 183.
22 Murakata, I.; Hara, A.; Ishii, T.; Amishiro, N. JP 2002275068, 2002 [Chem. Abstr. 2002, 136, 242161].
23 Fei, X.-F.; Wang, B.-X.; Takashi, I. Acta Pharm. Sin. 2002, 37, 673 (in Chinese).
(费晓方, 王本祥, 池岛乔, 药学学报, 2002,37, 673.)
24 Cai, S.-X.; Drewe, J. A.; Nguyen, B.; Reddy, P. S.; Pervin, A.WO 2002047690, 2002 [Chem, Abstr. 2002, 136, 47211].
25 Li, H.-L.; Zhang, H.-W.; Chen, D.-D.; Zhong, L.; Ren, X.-D.;St-Tu, R. Acta Pharmacol. Sin. 2002, 23,631.
26 Xu, L.; Yao, M.-H. World Pharmacy 2001, 22, 335 (in Chinese).
(徐璐, 姚明辉, 国外医药:合成药, 生化药, 制剂分册, 2001, 22, 335.)
27 Cai, S.-X.; Nguyen, B.; Jia, S.-J.; Herich, J.; Guastella, J.;Reddy, S.; Tseng, B.; Drewe, J.; Kasibhatla, S. J. Med. Chem. 2003, 46, 2474.
28 Adany, I.; Yazlovitskaya, E. M.; Haug, J. S.; Voziyan, P. A.; Melnykovych, G. Cancer Lett. 1994, 79, 175.
29 Hamada, M.; Nishio, K.; Doe, M.; Usuki, Y.; Tanaka, T. FEBS Lett. 2002, 514, 250.
30 Miao, J.-Y.; Araki, S.; Zhang, H.-W.; Hayashi, H. Acta Pharmacol. Sin. 1999, 20, 107.
31 Zhu, J.-W.; Nagasawa, H.; Nagura, F.; Mohamad, S. B.; Uto, Y.;Ohkura, K.; Hori, H. Bioorg. Med. Chem. 2002, 8, 455.
32 Ryo, M.; Taijiro, T.; Kazuo, S. Y.; Junko, S.; Takayuki, K.; Haruo, S.; Yoichi, H. J. Antibiot. 2001, 54, 714. [Chem. Abstr. 2002, 136, 82570].
33 Chen, Y.-C.; Shen, S.-C.; Lee, W. R.; Hsu, F. L.; Lin, H. Y.;Ko, C. H.; Tseng, S. W. Biochem. Pharmacol. 2002, 64,1713.
34 Leoni, L. M.; Hamel, E.; Genini, D.; Shih, H.; Carrera, C. J.; Cottam, H. B.; Carson, D. A. J. Natl. Cancer Inst. 2000, 92, 217.
35 Simon, D.; Roberti, M.; Invidiata, F. P.; Rondanin, R.; Baruchello, R.; Malagutti, C.; Mazzali, A.; Rossi, M.; Grimaudo, S.; Dusonchet, L.; Meli, M.; Raimondi, M. V.; Alessandro, N. D.; Tolomeo, M. Bioorg. Med. Chem. Lett. 2000, 10, 2669.
36 Nakagawa, K.; Sowa, Y.; Kurobe, M.; Ozono, K.; Siu-Caldera, M.L.; Reddy, G. S.; Uskokovic, M. R.; Okano, T. Steroids 2001, 66, 327.
37 Li, M.-Y.; Wang, H.-Y.; Liu, G.-Q. Acta Pharmacol. Sin.2001, 22, 1018.
38 Hidehiko, F.; Toshinori, A.; Hideyuki, S.; Isshin, T.; Hiroshi,F. JP 2002080446 2002 [Chem. Abstr. 2002, 136, 241649].
39 Cao, H.-Z.; Li, Z.-Y. Chin. J. Org. Chem. 2002,22, 11 (in Chinese).
(曹鸿志, 李祖义, 有机化学, 2002, 22, 11.)
40 Koichi, O.; Masahiro, M. JP 2002179579, 2002 [Chem. Abstr. 2002, 136, 41727].
41 Umezawa, K.; Nakazawa, K.; Ikeda, Y.; Naganawa, H.; Kondo, S. J. Org. Chem. 1999, 64, 3034.
42 Noguchi, Y.; Uchiro, H.; Yamada, T.; Kobayashi, S. TetrahedronLett. 2001, 42, 5253.
43 Lorca, M.; Kurosu, M. Tetrahedron Lett. 2001, 42, 2431.
44 Miao, J.-Y.; Zhang, J.; Zhang, S.-L.; Du, C.-Q.; Zhao, K.-W.J. Shandong Univ. (Health Sci.) 2002, 40, 103 (in Chinese).
(苗俊英, 张捷, 张尚立, 杜青春, 赵克温, 山东大学学报医学版,2002, 40, 103.)

[1]	Haibo Huo, Guixia Li, Shijun Wang, Chun Han, Baojun Shi, Jian Li. Novel γ-Carboline Derivatives as Antibacterial Agents: Synthesis and Antibacterial Evaluation [J]. Chinese Journal of Organic Chemistry, 2024, 44(1): 204-215.
[2]	Yan Tian, Rui Dong, Peng Nie, Bo Xu. Synthesis and Characterization of Ruthenium Germyl Complexes with Various Substituents [J]. Chinese Journal of Organic Chemistry, 2024, 44(1): 173-179.
[3]	Shutong Zhou, Shengnan Tu, Zijian Gao, Yemei Wang, Shasha Sun. Research Progress in Synthesis, Properties and Application of Subphthalocyanine [J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2628-2646.
[4]	Xin Zuo, Shinuo Xu, Zhongyang Chen, Jianfeng Yan, Yaofeng Yuan. Research Progress of Electron Transport Properties in Ferrocene- Containing Single-Molecule Junctions [J]. Chinese Journal of Organic Chemistry, 2023, 43(7): 2313-2322.
[5]	Jinyan He, Fuyun Tian, Qingqing Wu, Yueming Zheng, Yuting Chen, Haiyan Xu, Zhengsheng Jin, Li Zhan, Xinqiang Cheng, Yueling Gu, Zhaobing Gao, Guilong Zhao. Design, Synthesis and Bioactivity of [3.3.3]Propellane-Based Voltage-Gated Calcium Channel α2δ Subunit Ligands [J]. Chinese Journal of Organic Chemistry, 2023, 43(6): 2226-2238.
[6]	Yumei Zhong, Xiaoying Zou, Xiaoya Zhuo, Yihan Wang, Jiayi Shen, Lüyin Zheng, Wei Guo. Design, Synthesis and in vitro Anti-Cancer Activity of Novel Ethyl 4-Oxo-2-iminothiazolidin-5-ylidene Acetates [J]. Chinese Journal of Organic Chemistry, 2023, 43(4): 1452-1461.
[7]	Qifan Wang, Yuanquan Zhang, Li Xing, Yuanxiang Zhou, Chenyu Gong, Bangcan He, Nian Zhang, Yongjun Wu, Wei Xue. Design, Synthesis and Biological Activity of Myricetin Derivatives Containing 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazole [J]. Chinese Journal of Organic Chemistry, 2023, 43(4): 1525-1536.
[8]	Xingzhou Liu, Mingjia Yu, Jianhua Liang. Research Progress on the Synthesis of Protoberberine Skeleton and Its Anti-inflammatory Activity [J]. Chinese Journal of Organic Chemistry, 2023, 43(4): 1325-1340.
[9]	Yushan Zhang, Zhen Huan, Jindong Yang, Jinpei Cheng. Recent Advances in Hydrogen Transfer Reactivities of N-Heterocyclic Phosphines [J]. Chinese Journal of Organic Chemistry, 2023, 43(11): 3806-3825.
[10]	Weiqin Liu, Lihui Shao, Chengpeng Li, Yayu Zou, Haitao Long, Yan Li, Qiangsheng Ge, Zhenchao Wang, Guiping Ouyang. Synthesis and Antitumor Activity of 3-Hydrazone Quinazolinone Derivatives [J]. Chinese Journal of Organic Chemistry, 2023, 43(1): 214-222.
[11]	Xiang Li, Kai Zhu, Qing Han, Xingxing Lu, Mingjun Li, Yun Ling, Hongxia Duan. Design, Synthesis and Bioactivity Study on Novel Furan α-Butenolactone Compounds [J]. Chinese Journal of Organic Chemistry, 2023, 43(1): 202-213.
[12]	Jing Wang, Linlin Wu, Qian Wang. Synthesis and Characterization of New Indeno[1,2-b]fluorene-6,12-dione Derivatives [J]. Chinese Journal of Organic Chemistry, 2023, 43(1): 223-228.
[13]	Rong Zhang, Xiang Gao, Lingling Chen, Fajun Nan. Discovery and Structure-Activity Relationship Studies of Thiazole- Oxazole Tandem Heterocyclic RNA Splicing Inhibitors [J]. Chinese Journal of Organic Chemistry, 2022, 42(9): 2925-2939.
[14]	Jing Zhao, Zhe Jin, Run Wang, Xin'geng Zhang, Yingmei Han, Chun Hu, Xiaoping Liu, Chuanming Zhang, Liping Jin. Design, Synthesis and Anticancer Activity of 2-((Pyridin- 2-ylmethyl)thio)-1H-benzimidazole Derivatives [J]. Chinese Journal of Organic Chemistry, 2022, 42(7): 2172-2183.
[15]	Ming Cai, Liang Shao, Fan Yang, Jihong Zhang, Fei Yu. Design, Synthesis of Pentacyclic Triterpenoid Glucose Conjugate and in vitro Activity against Influenza Virus [J]. Chinese Journal of Organic Chemistry, 2022, 42(5): 1453-1462.

细胞凋亡诱导剂研究进展

Recent Developments of Apoptosis Inducer

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments