Synthesis and Fungicidal Activities of 2-Alkoxy-3H-quinazolin-4-ones

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (8): 923-926. Previous Articles Next Articles

2-烷氧基-3H-喹唑啉-4-酮的合成与杀菌活性

丁明武^*, 杨尚君, 陈云峰

华中师范大学化学学院武汉 430079

收稿日期:2003-09-15 修回日期:2004-01-07 接受日期:2004-03-09 发布日期:2022-09-20
通讯作者: * E-mail: ding5229@yahoo.com.cn
基金资助:
国家自然科学基金(No. 20102001)资助项目.

Synthesis and Fungicidal Activities of 2-Alkoxy-3H-quinazolin-4-ones

DING Ming-Wu^*, YANG Shang-Jun, CHEN Yun-Feng

College of Chemistry, Central China Normal University, Wuhan 430079

Received:2003-09-15 Revised:2004-01-07 Accepted:2004-03-09 Published:2022-09-20

Abstract

Twelve unreported 2-alkoxy-3H-quinazolin-4-ones 4 were synthesized by a new synthetic method, which included aza-Wittig reaction of iminophosphorane 1 with aromatic isocynates to give carbodiimides 2 and subsequent reaction of 2 with various ROH in presence of catalytic NaOR. The structure of 4 was confirmed by ¹H NMR, MS and IR analysis. The conditions of cyclization and the biologicalactivities of these new compounds synthesized were investigated. The results showed that most of the compounds 4 exhibited good fungicidal activities.For example, 4l exhibited 89% inhibition of Pellicularia sasakii in 50 mg/L.

Key words: 3H-quinazolin-4-one, aza-Wittig reaction, fungicidal activity

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DING Ming-Wu, YANG Shang-Jun, CHEN Yun-Feng. Synthesis and Fungicidal Activities of 2-Alkoxy-3H-quinazolin-4-ones[J]. Chinese Journal of Organic Chemistry, 2004, 24(8): 923-926.

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2-烷氧基-3H-喹唑啉-4-酮的合成与杀菌活性

Synthesis and Fungicidal Activities of 2-Alkoxy-3H-quinazolin-4-ones

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