Knoevenagel Reaction of Pyropheophorbide and Synthesis of Its Heterocyclo-substituted Derivatives

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (03): 313-318. Previous Articles Next Articles

Original Articles

焦脱镁叶绿酸的Knoevenagel反应及其杂环取代衍生物的合成

王进军*^,1，邬旭然¹，韩光范²，沈荣基³

(¹烟台大学应用化学系烟台 264005)
(² 江苏科技大学镇江 212003)
(³ 仁济大学微工程学院釜山韩国)

收稿日期:2004-05-10 修回日期:2004-09-30 发布日期:2005-02-28
通讯作者: 王进军

Knoevenagel Reaction of Pyropheophorbide and Synthesis of Its Heterocyclo-substituted Derivatives

WANG Jin-Jun*^,1,WU Xu-Ran¹,HAN Guang-Fan²,SHIM Young Key³

(¹ Department of Applied Chemistry, Yantai University, Yantai 264005)
(² University of Science and Technology of Jiangsu, Zhenjiang 212032)
(³School of Nano Engineering, Inji University, Pusan, Ko-rea)

Received:2004-05-10 Revised:2004-09-30 Published:2005-02-28
Contact: WANG Jin-Jun

Abstract

Methyl pyropheophorbide-d was used as starting material and the Knoevenagel reaction of the aldehyde group on pyropheophorbide with active methylene group in β-diketone, α-cyanoketone or malono- nitrile was carried out to complete the synthesis of derivatives of methyl pyropheophorbide-a substituted with five-membered heterocycle at 3-positipon. The structures of all these new compounds were characterized by elemental analysis, UV, IR and ¹H NMR spectra.

Key words: Knoevenagel reaction, photodynamic therapy, pyropheophorbide

Cite this article

WANG Jin-Jun*^,1,WU Xu-Ran,HAN Guang-Fan²,SHIM Young Key³. Knoevenagel Reaction of Pyropheophorbide and Synthesis of Its Heterocyclo-substituted Derivatives[J]. Chin. J. Org. Chem., 2005, 25(03): 313-318.

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焦脱镁叶绿酸的Knoevenagel反应及其杂环取代衍生物的合成

Knoevenagel Reaction of Pyropheophorbide and Synthesis of Its Heterocyclo-substituted Derivatives

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