Syntheses and α-Glucosidase Inhibitions of Aldisin and Its Derivatives

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (08): 954-958. Previous Articles Next Articles

Original Articles

Aldisin及其衍生物的合成和α-葡萄糖苷酶抑制活性研究

曾向潮*，徐石海，李毅群，王渝芳

(¹暨南大学化学系广州 510632)
(²中山大学化学与化学工程学院广州 510275)

收稿日期:2004-07-01 修回日期:2005-03-04 发布日期:2005-07-30
通讯作者: 曾向潮

Syntheses and α-Glucosidase Inhibitions of Aldisin and Its Derivatives

ZENG Xiang-Chao*,XU Shi-Hai,LI Yi-Qun,WANG Yu-Fang

(¹Department of Chemistry, Jinan University, Guangzhou 510632)
(²School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275)

Received:2004-07-01 Revised:2005-03-04 Published:2005-07-30
Contact: ZENG Xiang-Chao

Abstract

Aldisin (6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione) and its derivatives, 1-methy-
laldisin and 3-bromoaldisin, were synthesized by cyclization of 3-[(pyrrole-2-carbonyl)amino] propionic acids in phosphorus oxychloride under reflux. Their structures were characterized by ¹H NMR, ¹³C NMR, FABMS, IR spectra and elemental analy-sis. The crystal structure of 1-methylaldisin was determined by single-crystal X-ray diffraction. And the α-glucosidase inhibitions of these compounds have also been studied.

Key words: aldisin, cyclization, α-glucosidase, crystal structure, 1-methylaldisin

Cite this article

ZENG Xiang-Chao*,XU Shi-Hai,LI Yi-Qun,WANG Yu-Fang. Syntheses and α-Glucosidase Inhibitions of Aldisin and Its Derivatives[J]. Chin. J. Org. Chem., 2005, 25(08): 954-958.

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Aldisin及其衍生物的合成和α-葡萄糖苷酶抑制活性研究

Syntheses and α-Glucosidase Inhibitions of Aldisin and Its Derivatives

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