Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (11): 1392-1397. Previous Articles     Next Articles

Original Articles

1,3-偶极环加成法合成异噁唑啉新化合物及其生物活性的研究

程春生*,1,2,李志念2,苏金燕2,李涛2,张宝砚1   

  1. (1东北大学理学院 沈阳 110004)
    (2沈阳化工研究院 沈阳 110021)
  • 收稿日期:2005-04-20 修回日期:2005-05-23 发布日期:2005-10-30
  • 通讯作者: 程春生

Synthesis of Isoxazolines by 1,3-Dipolar Cycloaddition andTheir Bioactivity

CHENG Chun-Sheng*,1,2,LI Zhi-Nian2,SU Jin-Yan2,LI Tao2,ZHANG Bao-Yan1   

  1. (1 School of Sciences, Northeastern University, Shenyang 110004)
    (2 Shenyang Research Institute of Chemical Industry, Shenyang 110021)
  • Received:2005-04-20 Revised:2005-05-23 Published:2005-10-30
  • Contact: CHENG Chun-Sheng

A series of new isoxazolines were prepared by 1,3-dipolar cycloaddition between different mono-substituted styrenes and new 1,3-dipolar compounds which were synthesized by the reaction of N-methylhydroxylamine sulfate with aromatic carbonyl compounds. This synthetic pathway of 5-substituted isoxazolines was an good process in green chemistry. The chemical structures of these products were characterized by 1H NMR, 13C NMR, COSY, HSQC and DEPT. Their bioactivity has been tested also in the laboratory, finding that some new compounds inhibited Botrytis Cinerea effectively.

Key words: NMR, MS, bioactivity, isoxazoline, 1,3-dipolar cycloaddition