Synthesis and Fungicidal Evaluation of Novel 1,2,4-Triazolo[1,5-a]- pyrimidine Containing Oxadiazolyl De-rivatives

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (11): 1477-1481. Previous Articles Next Articles

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含噁二唑杂环取代的新型三唑并嘧啶衍生物的合成及其生物活性

陈悟¹，陈琼²，吴琼友²，杨光富*^,2

(¹华中科技大学生命科学与技术学院武汉 430074)
(²华中师范大学化学学院农药与化学生物学教育部重点实验室武汉 430079)

收稿日期:2005-04-02 修回日期:2005-05-23 发布日期:2005-10-30
通讯作者: 杨光富

Synthesis and Fungicidal Evaluation of Novel 1,2,4-Triazolo[1,5-a]- pyrimidine Containing Oxadiazolyl De-rivatives

CHEN Wu¹,CHEN Qiong²,WU Qiong-You²,YANG Guang-Fu*^,2

(¹ College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074)
(²Key Laboratory of Pesticide & Chemical Biology, Ministry of Educa-tion, College of Chemistry, Central China Normal
University, Wuhan 430079)

Received:2005-04-02 Revised:2005-05-23 Published:2005-10-30
Contact: YANG Guang-Fu

Abstract

Reaction of 2-hydrazinocarbonylmethenethio-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine with carbon disulfide in refluxing ethanol afforded 2-(5-mercapto-1,3,4-oxadiazol-2-ylmethylthio)-5,7-di-methyl-1,2,4-triazolo[1,5-a]pyrimidine, which was then treated with various benzyl halide in basic condition to yield 17 novel biheterocyclic derivatives. The structures of all compounds obtained were con-firmed by elemental analyses, ¹H NMR and MS. Preliminary bioassay indicates that some compounds display antibacterial activity to certain extent.

Key words: 1,3,4-oxadiazole, bioactivity, 1,2,4-triazolo[1,5-a]pyrimidine

Cite this article

CHEN Wu,CHEN Qiong²,WU Qiong-You²,YANG Guang-Fu*^,2. Synthesis and Fungicidal Evaluation of Novel 1,2,4-Triazolo[1,5-a]- pyrimidine Containing Oxadiazolyl De-rivatives[J]. Chin. J. Org. Chem., 2005, 25(11): 1477-1481.

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含噁二唑杂环取代的新型三唑并嘧啶衍生物的合成及其生物活性

Synthesis and Fungicidal Evaluation of Novel 1,2,4-Triazolo[1,5-a]- pyrimidine Containing Oxadiazolyl De-rivatives

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