Green Synthesis of O,O'-Dialkyl α-(4-Trifluoromethylanilino)-substitutented Benzylphos-phonate

Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (08): 1136-1139. Previous Articles Next Articles

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O,O'-二烷基-α-(4-三氟甲基苯基)氨基-取代苯基甲基膦酸酯的绿色合成研究

万琼琼，宋宝安*，张国平，金林红
胡德禹，杨松，刘刚

(贵州大学精细化工研究开发中心教育部绿色农药和农业生物工程重点实验室贵阳 550025)

收稿日期:2005-10-02 修回日期:2006-03-06 发布日期:2006-07-26
通讯作者: 宋宝安

Green Synthesis of O,O'-Dialkyl α-(4-Trifluoromethylanilino)-substitutented Benzylphos-phonate

WAN Qiong-Qiong,SONG Bao-An*,ZHANG Guo-Ping,JIN Lin-Hong
HU De-Yu,YANG Song,LIU Gang

(Key Laboratory of Green Pesticide and Agricultural Bioengineering of Ministry of Education, Research and
Development Center of Fine Chemicals, Guizhou University, Guiyang 550025)

Received:2005-10-02 Revised:2006-03-06 Published:2006-07-26
Contact: SONG Bao-An

Abstract

The Mannich-type addition of O,O'-dialky phosphite to 2-fluorobenzaldehyde and 4-trifluoro- methylaniline was carried out in one pot by means of adopting three kinds of green synthetic methods, microwave irradiation, ionic liquid and free solvent-catalyst condition. According to the results, the synthetic method was optimized without catalyst and solvent at 100 ℃ and 15 min, and it was economic, convenient, high yields, timesaving and environment friendly.

Key words: green synthesis, free solvent-catalyst, α-aminophosphonate

Cite this article

WAN Qiong-Qiong,SONG Bao-An*,ZHANG Guo-Ping,JIN Lin-Hong
HU De-Yu,YANG Song,LIU Gang. Green Synthesis of O,O'-Dialkyl α-(4-Trifluoromethylanilino)-substitutented Benzylphos-phonate[J]. Chin. J. Org. Chem., 2006, 26(08): 1136-1139.

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O,O'-二烷基-α-(4-三氟甲基苯基)氨基-取代苯基甲基膦酸酯的绿色合成研究

Green Synthesis of O,O'-Dialkyl α-(4-Trifluoromethylanilino)-substitutented Benzylphos-phonate

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