Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (01): 65-68. Previous Articles     Next Articles

Original Articles

β-榄香烯聚乙二醇衍生物的合成及体外抗癌活性

成康民,孙艳红,冯翠兰,沈玉梅*   

  1. (中国科学院上海应用物理研究所 上海 201800)
  • 收稿日期:2007-01-22 修回日期:1900-01-01 发布日期:2008-01-23
  • 通讯作者: 沈玉梅

Synthesis and in vitro Antiproliferative Activity of β-Elemene Polyethylene Glycol Derivatives

CHENG Kang-Min, SUN Yan-Hong, FENG Cui-Lan, SHEN Yu-Mei*   

  1. (Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800)
  • Received:2007-01-22 Revised:1900-01-01 Published:2008-01-23
  • Contact: SHEN Yu-Mei

A series of β-elemene monosubstituted polyethylene glycol (PEG) derivatives were prepared by the reaction of β-elemene with aminated PEG and characterized by IR, 1H NMR and 13C NMR spectra. Their in vitro antiproliferative activities towards K562 cell and Hela cell lines were evaluated by a WST-1 method, showing that their antiproliferative activities were improved compared to that of β-elemene.

Key words: polyethylene glycol, β-elemene derivative, antiproliferative activity