Synthesis of N-Phenyl and N-Ethoxycarbonylmethyl Phosphaisoqui-nolin-1-ones and Their Derivatives

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (10): 1744-1749. Previous Articles Next Articles

Original Articles

N-苯基和N-乙氧羰基甲基磷异喹啉酮及其衍生物的合成

丁一^a; 丁贻祥^*,b

(a上海师范大学生命与环境科学学院上海 200234)
(b中国科学院上海有机化学研究所上海 200032)

收稿日期:2008-03-17 修回日期:2008-04-28 发布日期:2008-10-20
通讯作者: 丁贻祥

Synthesis of N-Phenyl and N-Ethoxycarbonylmethyl Phosphaisoqui-nolin-1-ones and Their Derivatives

DING, Yi^a ; DING, Yi-Xiang^*,b

(a College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234)
(b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)

Received:2008-03-17 Revised:2008-04-28 Published:2008-10-20
Contact: DING, Yia

Abstract

Fifteen N-phenyl and N-ethoxycarbonylmethyl phosphaisoquinolin-1-ones and their 4-allyl, 4-chloro derivatives were synthesized by Pd(II)-catalyzed cyclization, coupling-cyclization and halocyclization reactions. The structures of the target compounds were confirmed by 1H NMR, 13C NMR, MS, IR spectra and elemental analysis.

Key words: N-ethyloxygencarbonylmethylphosphaisoquinolin-1-one, N-phenyphosphaisoquinolin-1-one, cyclization, 4-substituent phosphaisoquinolin-1-one, halocyclization, coupling-cyclization

Cite this article

DING, Yi^a ; DING, Yi-Xiang^*,b. Synthesis of N-Phenyl and N-Ethoxycarbonylmethyl Phosphaisoqui-nolin-1-ones and Their Derivatives[J]. Chin. J. Org. Chem., 2008, 28(10): 1744-1749.

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N-苯基和N-乙氧羰基甲基磷异喹啉酮及其衍生物的合成

Synthesis of N-Phenyl and N-Ethoxycarbonylmethyl Phosphaisoqui-nolin-1-ones and Their Derivatives

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