New liver targeted NO-releasing drugs can effectively repair liver damage. A series of novel liver targeted NO-releasing conjugates were designed and synthesized by conjugating the nitrated amino acids with the carboxyl group of cholic acid or ursodeoxycholic acid. The chemical structures of all new conjugates and intermediates were confirmed by elemental analysis, IR, 1H NMR and MS techniques. Their repairing activities to mice acute liver damage induced by acetaminophen and carbon tetrachloride were investigated.

Key words: bile acid, targeted drug, nitric oxide-releasing drug