Three-Component One-Pot Synthesis of 4-Aryl-3-methyl-1-phenyl- 4,5,6,7,8,9-hexahydropyrazolo[5,4-b]quinolin-5-one Derivatives in Aqueous Media

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (2): 261-265. Previous Articles Next Articles

Original Articles

水介质中4-芳基-3-甲基-1-苯基-4,5,6,7,8,9-六氢化吡唑并[5,4-b]喹啉-5-酮衍生物的三组分一锅合成

史达清*^,a,b,c，拾景文^b，姚浩^b，蒋虹^c，王香善^b,c

(^a苏州大学化学化工学院江苏省有机合成重点实验室苏州 215123)
(^b徐州师范大学化学系徐州 221116)
(^c江苏省药用植物生物技术重点实验室徐州 221116)

收稿日期:2007-01-17 修回日期:2007-06-07 发布日期:2008-02-01
通讯作者: 史达清

Three-Component One-Pot Synthesis of 4-Aryl-3-methyl-1-phenyl- 4,5,6,7,8,9-hexahydropyrazolo[5,4-b]quinolin-5-one Derivatives in Aqueous Media

SHI Da-Qing*^,a,b,c,SHI Jing-Wen^b,YAO Hao^b,JIANG Hong^c,WANG Xiang-Shan^b,c

(^aKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical En-gineering,
Suzhou University, Suzhou 215123)
(^bDepartment of Chemistry, Xuzhou Normal University, Xuzhou 221116)
(^cKey Laboratory of Biotechnology on Medical Plants of Jiangsu Province, Xuzhou 221116)

Received:2007-01-17 Revised:2007-06-07 Published:2008-02-01
Contact: SHI Da-Qing

Abstract

4-Aryl-3-methyl-1-phenyl-4,5,6,7,8,9-hexahydropyrazolo[5,4-b]quinolin-5-one derivatives were synthesized by a three-component one-pot reaction of aromatic aldehydes, 5-amino-3-methyl-1- phenylpyrazole and 1,3-cyclohexanedione using sodium dodecanesulfonate (SDS) as a catalyst in aqueous media. The structures of products were identified by IR and ¹H NMR spectra, and the structure of 4e was confirmed by X-ray diffractional analysis.

Key words: three-component, 4,5,6,7,8,9-hexahydropyrazolo[5,4-b]quinolin-5-one, aqueous media, one-pot synthesis

Cite this article

SHI Da-Qing*^,a,b,c,SHI Jing-Wen^b,YAO Hao^b,JIANG Hong^c,WANG Xiang-Shan^b,c. Three-Component One-Pot Synthesis of 4-Aryl-3-methyl-1-phenyl- 4,5,6,7,8,9-hexahydropyrazolo[5,4-b]quinolin-5-one Derivatives in Aqueous Media[J]. Chin. J. Org. Chem., 2008, 28(2): 261-265.

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水介质中4-芳基-3-甲基-1-苯基-4,5,6,7,8,9-六氢化吡唑并[5,4-b]喹啉-5-酮衍生物的三组分一锅合成

Three-Component One-Pot Synthesis of 4-Aryl-3-methyl-1-phenyl- 4,5,6,7,8,9-hexahydropyrazolo[5,4-b]quinolin-5-one Derivatives in Aqueous Media

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