Microwave Assisted Synthesis and Antifungal, Anti-tumor Study of 2-(2,6-Dichlorophenyl)-1,3-thiazolidin-4-ones

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (01): 94-99. Previous Articles Next Articles

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2-(2’,6’-二氯苯基)-1,3-噻唑烷-4-酮衍生物的微波促进合成及抗真菌、抗肿瘤活性研究

陈华^*,a; 白洁^a ; 赵莲a ; 苑香果^a ; 李小六^*,a,b ; 曹克强^c

(a河北大学化学与环境科学学院河北省化学生物学重点实验室保定 071002)
(b河北大学化学与环境科学学院教育部药物化学与分子诊断省部共建重点实验室保定 071002)
(c河北农业大学植物保护学院保定 071001)

收稿日期:2008-04-25 修回日期:2008-05-15 发布日期:2009-01-20
通讯作者: 陈华;李小六

Microwave Assisted Synthesis and Antifungal, Anti-tumor Study of 2-(2,6-Dichlorophenyl)-1,3-thiazolidin-4-ones

Chen, Hua^*,a; Bai, Jie ^a; Zhao, Lian^a; Yuan, Xiangguo^a;
Li, Xiaoliu^*,a,b; Cao, Keqiang^c

(^a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Enviromental Science,
Hebei University, Baoding 071002)
(^b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, College of Chemistry and Envi-romental Science, Baoding 071002)
(^c College of Plant Protection, Hebei Agricultural University, Baoding 071002)

Received:2008-04-25 Revised:2008-05-15 Published:2009-01-20
Contact: Chen, Hua;Li, Xiaoliu

Abstract

A series of thiazolidin-4-ones with different group on the position N-3 were synthesized by a three-component cyclocondensation of 2,6-dichlorobenzaldehyde, amines and 2-mercaptoacetic acid using a microwave-assisted method. Some corresponding thiazolidin-4-thione derivatives were also prepared in the presence of Lawesson’s reagent. The structures of the synthesized compounds were confirmed by IR, 1H NMR, MS and elemental analysis. Antifungal (Sphaerotheca fusca Blum.) and cytotoxic activities against Hela cell of the compounds were evaluated, and some compounds showed good biological activities.

Key words: thiazolidin-4-one, antifungal, cytotoxic activity, microwave-assisted synthesis

Cite this article

Chen, Hua^*,a; Bai, Jie ^a; Zhao, Lian^a; Yuan, Xiangguo^a;
Li, Xiaoliu^*,a,b; Cao, Keqiang^c
. Microwave Assisted Synthesis and Antifungal, Anti-tumor Study of 2-(2,6-Dichlorophenyl)-1,3-thiazolidin-4-ones[J]. Chin. J. Org. Chem., 2009, 29(01): 94-99.

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2-(2’,6’-二氯苯基)-1,3-噻唑烷-4-酮衍生物的微波促进合成及抗真菌、抗肿瘤活性研究

Microwave Assisted Synthesis and Antifungal, Anti-tumor Study of 2-(2,6-Dichlorophenyl)-1,3-thiazolidin-4-ones

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2-(2’,6’-二氯苯基)-1,3-噻唑烷-4-酮衍生物的微波促进合成及抗真菌、 抗肿瘤活性研究

Microwave Assisted Synthesis and Antifungal, Anti-tumor Study of 2-(2,6-Dichlorophenyl)-1,3-thiazolidin-4-ones

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Knowledge

Cited

Abstract

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share this article

References

Related Articles 15

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2-(2’,6’-二氯苯基)-1,3-噻唑烷-4-酮衍生物的微波促进合成及抗真菌、抗肿瘤活性研究