A series of p-toluene sulfonylamido acetacylhydrazone derivatives were synthesized from p-toluenesulfonyl chloride which reacted with glycine to get the intermediate p-toluene sulfonylamido glycine, then through the esterification, hydrazinolysis to afford another intermediate p-toluene sulfonylamido acethydrazide, which condensed with different aldehydes to obtain the target compounds that were characterized by IR, 1H NMR, 13C NMR spectra and elemental analysis. The DFT-B3LYP methods with 6-31G* basis set have been applied to the advanced reaction energy, the charges distribution and the linear orbital level of the title compounds 4a～4g. The plant growth regulating activity tests showed that part of the compounds had good activity as plant growth regulator.

Key words: systhesis, p-toluene sulfonylamido acetacylhydrazone, quantum chemical calculation, biological activity