Synthesis and Vasodilatation of 2-Substituted-3,4- dihydro-1(2H)-isoquinolinones

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (06): 966-970. Previous Articles Next Articles

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2-取代-3,4-二氢-1-异喹啉酮的合成和舒张血管活性

张三奇^*,a; 李强^a; 祝丽永^b ; 曹永孝^a; 刘瑞熙^a ; 陈战国^b

(a西安交通大学医学院西安710061)
(b陕西师范大学化学与材料科学学院西安710062)

收稿日期:2008-05-13 修回日期:2008-12-10 发布日期:2009-06-20
通讯作者: 张三奇

Synthesis and Vasodilatation of 2-Substituted-3,4- dihydro-1(2H)-isoquinolinones

Zhang, Sanqi^*,a; Li, Qiang ^a; Zhu, Liyong^b; Cao, Yongxiao^a ;
Liu, Ruixi^a; Chen, Zhanguo^b

(a School of Medicine, Xi’an Jiaotong University, Xi’an 710061)
(b College of Chemistry & Materials Science, Shanxi Normal University, Xi’an 710062)

Received:2008-05-13 Revised:2008-12-10 Published:2009-06-20
Contact: Zhang, Sanqi

Abstract

2-Substituted-3,4-dihydro-1(2H)-isoquinolinones were synthesized from methyl 3-hydroxy-ben- zoates via allyl etherification, Claisen rearrangement, oxidation, reductive amination and aminolysis for the first time. The three steps, imine-formation, reduction and intramolecular amidation, were completed in one-pot at room temperature. The structures of the title compounds were characterized by 1H NMR, MS techniques and elemental analyses. Further more, myograph pharmacology methods demonstrated that several products exhibited the activity of vasodilatation.

Key words: Claisen rearrangement, one-pot method, vasodilatati, isoquinolinone

Cite this article

Zhang, Sanqi^*,a; Li, Qiang ^a; Zhu, Liyong^b; Cao, Yongxiao^a ;
Liu, Ruixi^a; Chen, Zhanguo^b
. Synthesis and Vasodilatation of 2-Substituted-3,4- dihydro-1(2H)-isoquinolinones[J]. Chin. J. Org. Chem., 2009, 29(06): 966-970.

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2-取代-3,4-二氢-1-异喹啉酮的合成和舒张血管活性

Synthesis and Vasodilatation of 2-Substituted-3,4- dihydro-1(2H)-isoquinolinones

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