Synthesis and Biological Activity of 1,5-Bis(substituted pyrazol-4-yl)- 1,4-pentadien-3-one Derivatives

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (9): 1412-1418. Previous Articles Next Articles

Original Articles

1,5-二取代吡唑基-1,4-戊二烯-3-酮类化合物的合成及生物活性研究

王振宁胡德禹宋宝安* 杨松金林红薛伟

(贵州大学精细化工研究开发中心教育部绿色农药与农业生物工程重点实验室贵阳 550025)

收稿日期:2008-07-27 修回日期:2009-01-13 发布日期:2009-12-30
通讯作者: 宋宝安

Synthesis and Biological Activity of 1,5-Bis(substituted pyrazol-4-yl)- 1,4-pentadien-3-one Derivatives

Wang, Zhenning Hu, Deyu Song, Baoan* Yang, Song Jin, Linhong Xue, Wei

(Key Laboratory of Green Pesticide and Agriclutural Bioengineering, Ministry of Education, Research and Development
Center for Fine Chemicals, Guizhou University, Guiyang 550025)

Received:2008-07-27 Revised:2009-01-13 Published:2009-12-30
Contact: Song, Baoan

Abstract

In order to find novel anti-TMV and antifungal compounds with high activity and low toxicity, thirteen new 1,5-bis(substituted pyrazol-4-yl)-1,4-pentadien-3-one derivatives were synthesized. Their structures were characterized by IR, 1H NMR spectra and elemental analysis. Preliminary bioassays indicated that some compounds showed moderate activity against TMV, and all compounds showed weak antifungal activity.

Key words: pyrazole, systhesis, bioactivity, 1,4-pentadien-3-one derivative

Cite this article

Wang, Zhenning Hu, Deyu Song, Baoan* Yang, Song Jin, Linhong Xue, Wei. Synthesis and Biological Activity of 1,5-Bis(substituted pyrazol-4-yl)- 1,4-pentadien-3-one Derivatives[J]. Chin. J. Org. Chem., 2009, 29(9): 1412-1418.

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1,5-二取代吡唑基-1,4-戊二烯-3-酮类化合物的合成及生物活性研究

Synthesis and Biological Activity of 1,5-Bis(substituted pyrazol-4-yl)- 1,4-pentadien-3-one Derivatives

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