Macrocyclic Diterpenes from Boswellia carterii Birdwood (Frankincense)

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (01): 107-111. Previous Articles Next Articles

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乳香大环二萜类化学成分研究

李福双，徐康平，袁寿洪，颜冬兰，刘让如，谭健兵，曾光尧，周应军，谭桂山*

(a中南大学药学院长沙 410013)
(b中南大学湘雅医院药剂科长沙 410008)

收稿日期:2008-09-24 修回日期:2009-04-24 发布日期:2010-01-20
通讯作者: 谭桂山 E-mail:tgs395@yahoo.com.cn
基金资助:
湖南省科技厅资助项目（编号：06sk3001）

Macrocyclic Diterpenes from Boswellia carterii Birdwood (Frankincense)

Li,Fushuang，Xu,Kangping，Yuan,Shouhong，Yan,Donglan，Liu,Rangru Tan,Jianbing，Zeng,Guangyao，Zhou,Yingjun，Tan,Guishan*

(^a School of Pharmaceutical Sciences，Central South University，Changsha 410013)
(^b Department of Pharmacy，Xiangya Hospital，Central South University，Changsha 410008)

Received:2008-09-24 Revised:2009-04-24 Published:2010-01-20

Abstract

Seven macrocyclic diterpene compounds were isolated from Boswellia carterii Birdwood (Frankincense) and purified by silica-gel column chromatorgraphy and preparative thin-layer chromatography (TLC)。Their structures were elucidated as incensole acetate (1)，incensole (2)，incensole oxide acetate (3)，isoincensole acetate (4)，incensole oxide (5)，isoincensole oxide (6) and isoincensolol (7)。Compound 7 was a novel compound and compound 4 was isolated from this genus for the first time。Compounds 1～7 suppressing Bel-7402，Hela and SW-480 cells were investigated in vitro with cytotoxic activity.

Key words: Boswellia carterii Birdwood (Frankincense), chemical constituent, macrocyclic diterpene, anti-tumor, isoincensolol

Cite this article

LI Fu-Shuang, XU Kang-Beng, YUAN Shou-Hong, YA Dong-Lan, LIU Rang-Ru, TAN Jian-Bing, CENG Guang-Yao, ZHOU Ying-Jun, TAN Gui-Shan. Macrocyclic Diterpenes from Boswellia carterii Birdwood (Frankincense)[J]. Chin. J. Org. Chem., 2010, 30(01): 107-111.

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乳香大环二萜类化学成分研究

Macrocyclic Diterpenes from Boswellia carterii Birdwood (Frankincense)

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