Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (01): 137-141. Previous Articles     Next Articles

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6-取代-3-(3,4,5-三甲氧基苯基)-1,2,4-三唑[3,4-b][1,3,4]噻二唑的合成与生物活性

杜海堂*,杜海军   

  1. (a天津大学理学院化学系 天津 300072) 
    (b贵阳学院化学系 贵阳 550003) 
    (c贵州民族学院化学与环境科学学院 贵阳 550025)
  • 收稿日期:2009-08-22 修回日期:2009-11-10 发布日期:2010-01-20
  • 通讯作者: 杜海堂 E-mail:haitangdu@163.com

Synthesis and Biological Activity of 6-(Substituted)-3-(3,4,5- trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

Du,Haitang*,Du,Haijun   

  1. (a Department of Chemistry,College of Sciences,Tianjin Universty,Tianjin 300072) 
    (b Department of Chemistry,Guiyang College,Guiyang 550003) 
    (c School of Chemistry and Environment Science,Guizhou University for Nationalites,Guiyang 550025)
  • Received:2009-08-22 Revised:2009-11-10 Published:2010-01-20
  • Contact: DU Hai-Tang E-mail:haitangdu@163.com

Eleven 6-(substituted)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives 5a~5k were synthesized by cyclization of 4-amino-5-(3,4,5-trimethoxybenzyl)-3-mercapto-1,2,4- triazole (4) with various substituted aromatic acids through a single step reaction。IR,1H NMR,MS techniques and elemental analysis confirmed the structures of the newly synthesized compounds。Preliminary bioassays indicated that some compounds showed fungicidal activity.

Key words: 4-amino triazole, triazolo thiadiazole, fungicidal activity