Enzymatic Synthesis of Vinyl Troxerutin Esters in Nonaqueous Medium

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (04): 551-557. Previous Articles Next Articles

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非水介质中曲克芦丁乙烯酯的酶促合成

肖咏梅*^{,1，栗俊田¹，毛璞¹，赵贞¹，林贤福²}

(¹河南工业大学化学化工学院郑州 450001)
(²浙江大学化学系杭州 310027)

收稿日期:2009-08-06 修回日期:2009-10-29 发布日期:2010-04-28
通讯作者: 肖咏梅 E-mail:henangongda@yahoo.com
基金资助:
河南省基础与前沿技术研究课题[072300420070]；河南省科技攻关[82102330014]

Enzymatic Synthesis of Vinyl Troxerutin Esters in Nonaqueous Medium

Xiao Yongmei*^,1 Li Juntian¹ Mao Pu¹ Zhao Zhen¹ Lin Xianfu²

(¹College of Chemistry & Chemical Engineering, Henan University of Technology, Zhengzhou 450001)
(²Department of Chemistry, Zhejiang University, Hangzhou 310027)

Received:2009-08-06 Revised:2009-10-29 Published:2010-04-28
Contact: XIAO Yong-Mei E-mail:henangongda@yahoo.com

Abstract

Through regioselective acylation of the primary hydroxyl groups in troxerutin, a series of vinyl troxerutin esters were synthesized in nonaqueous medium. The influence parameters such as enzyme source, the amount of the enzyme, solvents, chain length of acyl donors, water content of solvents and reaction time were investigated. The results indicated that alkaline protease from Bacillus subtilis performed highest activity in pyridine with water content lower than 1%. As decreasing of the chain length of the acyl donor, the transesterification reached equilibrium more rapidly and yields were improved.

Key words: troxerutin, enzymatic synthesis, regioselective, transesterification

Cite this article

XIAO Yong-Mei, LI Dun-Tian, MAO Pu, DIAO Zhen, LIN Xian-Fu. Enzymatic Synthesis of Vinyl Troxerutin Esters in Nonaqueous Medium[J]. Chin. J. Org. Chem., 2010, 30(04): 551-557.

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非水介质中曲克芦丁乙烯酯的酶促合成

Enzymatic Synthesis of Vinyl Troxerutin Esters in Nonaqueous Medium

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