Synthesis of 2,3-Diaryl-2,3-dihydroquinazolin-4(1H)-one Under Solvent-Free Conditions

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (9): 1405-1409. Previous Articles Next Articles

Notes

无溶剂条件下固相合成2,3-二芳基-2,3-二氢喹唑啉-4(1H)-酮

庄启亚¹，付永春²，唐丹¹，查云赟¹，荣良策*^{,1，屠树江*^,1}

(¹徐州师范大学化学化工学院徐州 221116)
(²河南商丘技师学院商丘 476000)

收稿日期:2010-06-08 修回日期:2010-07-18 发布日期:2010-09-03
通讯作者: 荣良策 E-mail:lcrong@xznu.edu.cn

Synthesis of 2,3-Diaryl-2,3-dihydroquinazolin-4(1H)-one Under Solvent-Free Conditions

Zhuang Qiya¹ Fu Yongchun² Tang Dan¹ Zha Yunyun¹ Rong Liangce*^,1 Tu Shujiang*^,1

(¹ College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116)
(² Shangqiu Technician Institute, Shangqiu 476000)

Received:2010-06-08 Revised:2010-07-18 Published:2010-09-03
Contact: Rong LiangCe E-mail:lcrong@xznu.edu.cn

Abstract

A series of 2,3-diaryl-2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized from isatiocanhydride and Schiff base in the presence of sodium hydroxide under solvent-free conditions. The ad-vantages of this procedure are simple protocol and high yields. Using different Schiff bases to prepare 2,3-diaryl-2,3-dihydroquinazolin-4(1H)-one derivatives, sixteen compounds were synthesized. The structures were determined by IR, ¹H NMR and HRMS techniques.

Key words: isatiocanhydride, Schiff base, quinazolin-4(1H)-one, solvent-free synthesis

Cite this article

ZHUANG Qi-Ya, FU Yong-Chun, TANG Dan, CHA Yun-Bin, RONG Liang-Ce, TU Shu-Jiang. Synthesis of 2,3-Diaryl-2,3-dihydroquinazolin-4(1H)-one Under Solvent-Free Conditions[J]. Chin. J. Org. Chem., 2010, 30(9): 1405-1409.

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无溶剂条件下固相合成2,3-二芳基-2,3-二氢喹唑啉-4(1H)-酮

Synthesis of 2,3-Diaryl-2,3-dihydroquinazolin-4(1H)-one Under Solvent-Free Conditions

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