Synthesis of 1,3-Aminoalcohols by One-Step Reduction of β-Enaminoketones with Lithium Aluminium Hydride

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (01): 106-109. Previous Articles Next Articles

Notes

氢化铝锂一步还原β-烯胺酮合成1,3-胺基醇

李爱军*，冯宝，刘倩春

(河北科技大学化学与制药工程学院石家庄 050018)

收稿日期:2010-04-09 修回日期:2010-05-25 发布日期:2010-08-05
通讯作者: 李爱军 E-mail:liaj@yeah.net

Synthesis of 1,3-Aminoalcohols by One-Step Reduction of β-Enaminoketones with Lithium Aluminium Hydride

LI Ai-Jun, FENG Bao, LIU Qian-Chun

(College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018)

Received:2010-04-09 Revised:2010-05-25 Published:2010-08-05
Contact: LI Ai-Jun E-mail:liaj@yeah.net

Abstract

β-Enaminoketones are important building blocks in organic synthetic chemistry and 1,3-aminoalcohols can be obtained by reduction of β-enaminoketones. Up to now lithium aluminium hydride can only reduce β-enaminoketones to 1,3-aminoalcohols by two-step reduction. Here, a new method for one- step reduction of 3-dimethylamino-1-arylprop-2-en-1-ones to 3-dimethylamino-1-aryl-1-propanols by lithium aluminium hydride with good yield is described.

Key words: 1,3-aminoalcohols, β-enaminoketones, reduction, lithium aluminium hydride

Cite this article

LI Ai-Jun, FENG Bao, LIU Qian-Chun. Synthesis of 1,3-Aminoalcohols by One-Step Reduction of β-Enaminoketones with Lithium Aluminium Hydride[J]. Chin. J. Org. Chem., 2011, 31(01): 106-109.

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氢化铝锂一步还原β-烯胺酮合成1,3-胺基醇

Synthesis of 1,3-Aminoalcohols by One-Step Reduction of β-Enaminoketones with Lithium Aluminium Hydride

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