Investigation on Novel Microwave-Assisted Synthesis Method Based on MCM-41 Microreactor

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (05): 690-694. Previous Articles Next Articles

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基于MCM-41微反应器的微波辅助合成新方法研究

肖尚友*，杨昊书，李倩倩，邱静，夏之宁

(重庆大学化学化工学院重庆 400030)

收稿日期:2010-09-05 修回日期:2010-12-07 发布日期:2010-12-23
通讯作者: 肖尚友 E-mail:xsy6508@163.com

Investigation on Novel Microwave-Assisted Synthesis Method Based on MCM-41 Microreactor

XIAO Shang-You, YANG Hao-Shu, LI Qian-Qian, QIU Jing, XIA Zhi-Ning

(College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030)

Received:2010-09-05 Revised:2010-12-07 Published:2010-12-23

MCM-41 mesoporous molecular sieve was synthesized under microwave irradiation and used as microreactor. 2-Hydroxyphenylacetic acid was assembled into MCM-41 microreactor in toluene solution, and benzofuran-2(3H)-one was obtained by the intramolecular esterification of 2-hydroxyphenylacetic acid with high selectivity. The reaction conditions including temperature, reaction time, microwave iradiation and so on were investigated. The yield of benzofuran-2(3H)-one was im-proved by 2～12 and 2～33 times in MCM-41 microreactor than that in solution under conventional heating and microwave irradiation respectively. In addition, the yield of the reaction in MCM-41 reactor under mi-crowave irradiation could be improved by 20%～100%.

Key words: MCM-41, microreactor, 2-hydroxyphenylacetic acid, benzofuran-2(3H)-one

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XIAO Shang-You, YANG Hao-Shu, LI Qian-Qian, QIU Jing, XIA Zhi-Ning. Investigation on Novel Microwave-Assisted Synthesis Method Based on MCM-41 Microreactor[J]. Chin. J. Org. Chem., 2011, 31(05): 690-694.

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基于MCM-41微反应器的微波辅助合成新方法研究

Investigation on Novel Microwave-Assisted Synthesis Method Based on MCM-41 Microreactor

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