Clean Synthesis of Quinazolinone Derivatives in Water Catalyzed by Yb(OTf)3

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (9): 1522-1526. Previous Articles Next Articles

Notes

水介质中Yb(OTf)₃催化下喹唑啉酮衍生物的绿色合成

王树良，盛洁，屠树江，王香善*

(徐州师范大学化学化工学院徐州 221116)

收稿日期:2011-03-16 修回日期:2011-05-18 发布日期:2011-06-29
通讯作者: 王香善 E-mail:xswang1974@yahoo.com;xswang@xznu.edu.cn

Clean Synthesis of Quinazolinone Derivatives in Water Catalyzed by Yb(OTf)₃

WANG Shu-Liang, SHENG Jie, TU Shu-Jiang, WANG Xiang-Shan

(School of Chemistry and Chemical Engineering, Xuzhou Normal University Xuzhou 221116)

Received:2011-03-16 Revised:2011-05-18 Published:2011-06-29
Contact: Wang Xiang-Shan E-mail:xswang1974@yahoo.com;xswang@xznu.edu.cn

Using water as a green reaction media, aldehydes or ketones react with 2-aminobenzohydrazide to give hydrazone firstly, and then a series of quinazolinone derivatives are obtained by the reaction of the hydrazone with another molecule of aldehyde or ketone catalyzed by 1 mol% Yb(OTf)₃. This method provides several advantages such as neutral conditions, high yields (80%～94 %), simple work-up and environmental benignity. The structures were established by spectroscopic data of IR, ¹H NMR and HRMS techniques.

Key words: 2-aminobenzohydrazide, quinazolinone, water, Yb(OTf)₃

Cite this article

WANG Shu-Liang, SHENG Jie, TU Shu-Jiang, WANG Xiang-Shan. Clean Synthesis of Quinazolinone Derivatives in Water Catalyzed by Yb(OTf)₃[J]. Chin. J. Org. Chem., 2011, 31(9): 1522-1526.

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水介质中Yb(OTf)₃催化下喹唑啉酮衍生物的绿色合成

Clean Synthesis of Quinazolinone Derivatives in Water Catalyzed by Yb(OTf)₃

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水介质中Yb(OTf)3催化下喹唑啉酮衍生物的绿色合成