A series of hydrazone compounds containing tetrazole ring were synthesized rapidly in high yields under the condition of microwave irradiation and confirmed by elemental analysis, IR, ¹H NMR and ¹³C NMR spectra. The crystal structure of compound 4a was determined by X-ray diffraction method. It belongs to triclinic system with space group P-1, a＝0.7382(1) nm, b＝0.9992(2) nm, c＝1.1535(2) nm, α＝81.41(2)°, β＝85.72(2)°, γ＝72.21(2)°, D_c＝1.404 g•cm^－3, V＝0.8007(38) nm^－3, Z＝2. The crystal structure shows that the compound has trans configuration and characteristic dimers connected by intermolecular hydrogen bond. The bioassay result indicates that some of the compounds have relatively low antibacterial activity.

Key words: acylhydrazone, microwave irradiation, bioactivity, tetrazole