Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (04): 477-481. Previous Articles     Next Articles

Review

芳醛-N-(1-苯基-1H-四唑-5-巯基)乙酰腙的微波合成及其晶体结构

魏太保,李满林,林奇,刘洪,张有明*   

  1. (西北师范大学化学化工学院 甘肃省高分子材料重点实验室 兰州 730070)
  • 收稿日期:2005-06-08 修回日期:2005-10-25 发布日期:2006-03-31

Microwave Assisted Synthesis and Crystal Structure of Arylal-dehyde- N-(1-phenyl-1H-tetrazole-5-yl)thiol Acetyl Hy-drazones

WEI Tai-Bao,LI Man-Lin,LIN Qi,LIU Hong,ZHANG You-Ming*   

  1. (Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering,
    Northwest Normal University, Lanzhou 730070)
  • Received:2005-06-08 Revised:2005-10-25 Published:2006-03-31

A series of hydrazone compounds containing tetrazole ring were synthesized rapidly in high yields under the condition of microwave irradiation and confirmed by elemental analysis, IR, 1H NMR and 13C NMR spectra. The crystal structure of compound 4a was determined by X-ray diffraction method. It belongs to triclinic system with space group P-1, a=0.7382(1) nm, b=0.9992(2) nm, c=1.1535(2) nm, α=81.41(2)°, β=85.72(2)°, γ=72.21(2)°, Dc=1.404 g•cm-3, V=0.8007(38) nm-3, Z=2. The crystal structure shows that the compound has trans configuration and characteristic dimers connected by intermolecular hydrogen bond. The bioassay result indicates that some of the compounds have relatively low antibacterial activity.

Key words: acylhydrazone, microwave irradiation, bioactivity, tetrazole