Chin. J. Org. Chem. ›› 1998, Vol. 18 ›› Issue (5): 469-472. Previous Articles     Next Articles

Original Articles

环氧酰胺类化合物在OD和AD柱上手性拆分的比较

夏立钧;周永贵;唐民华;林琳;戴立信   

  1. 中国科学院上海有机化学研究所.上海(200032)
  • 发布日期:1998-10-25

Comparison of enantiomeric resolution of 2, 3-epoxideamides by HPLC on Chiralpak OD and Chiralcel AD chiral stationary phase

Xia Lijun;Zhou Yonggui;Tang Minhua;Lin Lin;Dai Lixin   

  1. Shanghai Inst Organ Chem., CAS.Shanghai(200032)
  • Published:1998-10-25

The optical resolution of racemic mixtures of thirteen 2, 3- epoxideamides with different substituting group was achieved with HPLC by using Chiralcel OD and Chiralpak AD as chiral stationary phase and hexane/2-propanol mixtures with different concentrations as eluent. The chromatographic parameters of theseracemates on AD and OD columns were examined. The results showed that the chiral recognization process was the sum of all the possible chiral interactions (the dipole-dipole, hydrogen bond and π-π interactions) and achiral interaction (such as steric effect) between 2, 3- epoxideamides and the chiral stationary phase. This method had been applied to identify the optical purity of 2, 3-epoxideamides.

Key words: ELUENT, CHIRAL REAGENT, ISOPROPANOL, AMIDES P, HEXANE, EPOXIDE, ENANTIOMORPH, STATIONARY PHASE, MESOTOMY, HIGH-SPEED LIQUID CHROMATOGRAPHY

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