Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (02): 216-221. Previous Articles     Next Articles

Original Articles

对甲苯磺酰胺基乙酰腙类化合物的生物活性及其量子化学计算

魏太保 ; 冷艳丽; 王永成; 张建辉; 张有明*   

  1. (西北师范大学化学化工学院 甘肃省高分子材料重点实验室 兰州 730070)
  • 收稿日期:2008-01-18 修回日期:2008-07-18 发布日期:2009-02-20
  • 通讯作者: 张有明

Biology Activity and Quantum Chemical Calculation of p-Toluene Sulfonylamido Acetacylhydrazone Derivatives

Wei, Taibao ; Leng, Yanli; Wang, Yongcheng;
Zhang, Jianhui ; Zhang, Youming*
  

  1. (Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering,
    Northwest Normal University, Lanzhou 730070)
  • Received:2008-01-18 Revised:2008-07-18 Published:2009-02-20
  • Contact: Zhang, Youming

A series of p-toluene sulfonylamido acetacylhydrazone derivatives were synthesized from p-toluenesulfonyl chloride which reacted with glycine to get the intermediate p-toluene sulfonylamido glycine, then through the esterification, hydrazinolysis to afford another intermediate p-toluene sulfonylamido acethydrazide, which condensed with different aldehydes to obtain the target compounds that were characterized by IR, 1H NMR, 13C NMR spectra and elemental analysis. The DFT-B3LYP methods with 6-31G* basis set have been applied to the advanced reaction energy, the charges distribution and the linear orbital level of the title compounds 4a~4g. The plant growth regulating activity tests showed that part of the compounds had good activity as plant growth regulator.

Key words: systhesis, p-toluene sulfonylamido acetacylhydrazone, quantum chemical calculation, biological activity