Chin. J. Org. Chem. ›› 1987, Vol. 7 ›› Issue (1): 70-72. Previous Articles     Next Articles

4-取代硫脲基-2,2,6,6-四甲基哌啶氮氧自由基化合物的合成

张自义;杨虎;谭龙泉;刘力生;郑荣粱;宋勤   

  1. 兰州大学化学系;兰州大学生物系
  • 发布日期:1987-02-25

Synthesis of some 4-thiouredo-2,2,6,6-tetramethyl-piperidine-1-oxyls

ZHANG ZIYI;YANG HU;TAN LONGQUAN;LIU LISHENG;ZHENG RONGLIANG;SONG QING   

  • Published:1987-02-25

Title compounds I (R1R2N = NBu2, NEt2, piperidino, morpholino, cyclohexylamino) were prepared in 60-87% yield by refluxing isothiocyanate II with R1R2NH in EtOH. I (R1R2N = NBu2) showed 48% inhibition against L7712-leukemia cell at 50 mg/mL.

Key words: PIPERIDINE P, ANTICARCINOGEN, OXYGEN, INFRARED SPECTROPHOTOMETRY, ELECTRON SPIN RESONANCE SPECTROMETRY, NITROGEN, ELEMENTAL ANALYSIS, LEUKEMIA, THIOUREAS, FREE RADICAL

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