Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (1): 85-110.DOI: 10.6023/cjoc202307004 Previous Articles     Next Articles



金玉坤a, 任保轶a,*(), 梁福顺b,*()   

  1. a 沈阳化工大学理学院 沈阳 110142
    b 辽宁大学化学院 沈阳 110036
  • 收稿日期:2023-07-08 修回日期:2023-08-12 发布日期:2023-09-08
  • 基金资助:

Visible Light-Mediated Selective C—F Bond Cleavage of Trifluoromethyl Groups and Its Application in Synthesizing gem-Difluoro-Containing Compounds

Yukun Jina, Baoyi Rena(), Fushun Liangb()   

  1. a College of Science, Shenyang University of Chemical Technology, Shenyang 110142
    b College of Chemistry, Liaoning University, Shenyang 110036
  • Received:2023-07-08 Revised:2023-08-12 Published:2023-09-08
  • Contact: *E-mail:; E-mail:
  • Supported by:
    Natural Science Foundation of Liaoning Province(2021-MS-254)

The unique properties of difluorinated compounds have attracted widespread attention in the fields of medicine and material sciences. The conversion of inexpensive and easily available trifluoromethyl groups into difluoro groups is of great importance in organic synthesis. However, there still exist great challenges in the selective cleavage of C—F bonds, because the dissociation energy of single C—F bond in trifluoromethyl group is much higher than that of the C—F bond in the difluoro unit of the generated product. Thus, the selective cleavage of C—F bond is difficult to control, which can easily lead to excessive defluorination. Compared with the traditional thermal reaction, the visible-light irradiated reaction provides an alternative pathway to achieve C—F cleavage more efficiently and selectively. The research progress on the selective cleavage of C—F bonds mediated by visible light in the past three years is summarized and its future perspective is prospected.

Key words: photocatalysis, free radical, C—F fracture, germinal difluoro-compound, synthesis