Chin. J. Org. Chem. ›› 1988, Vol. 8 ›› Issue (1): 41-42. Previous Articles     Next Articles

相转移催化法合成β-内酰胺

管作武;华美;梁景成;都燕霞;陈萌   

  1. 北京医科大学药学院;中国医学科学院抗菌素研究所
  • 发布日期:1988-02-25

Synthesis of β-lactam under phase transfer catalysis

GUAN ZUOWU;HUA MEI;LIANG JINGCHENG;DOU YANXIA;CHEN MENG   

  • Published:1988-02-25

Stirring amides I (R = H, 4-Me, 4-MeO, 4-Cl, 4-Br, 3-Me, 4-iodo) with 50% NaOH and type 717 anion exchange resin in CH2Cl2 at room temperature for 90 h gave 37-90% b-lactams II.

Key words: AMIDES, PHASE TRANSFER CATALYSIS, CYCLIZATION, CATION EXCHANGE RESINS, HALOHYDROCARBON, BETA LACTAM

CLC Number: