Chin. J. Org. Chem. ›› 1989, Vol. 9 ›› Issue (3): 266-268. Previous Articles     Next Articles

冠醚-CuI混合催化剂的组份对溴代雌甾的亲核取代反应的影响

罗光荣;陈淑华;赵华明   

  1. 四川大学化学系
  • 发布日期:1989-06-25

Effect of components of crown-CuI mixed catalyst on nucleophilic substitution of bromoestrogen

LUO GUANGRONG;CHEN SHUHUA;ZHAO HUAMING   

  • Published:1989-06-25

Nucleophilic substitution of bromoestrogen with NaOMe in the presence of CuI and benzo-15-crown-5, 15-crown-5, dibenzo-18-crown-6, or 18-crown-6 was reported. Thus, stirring bromides I (R = Br) with NaOMe, CuI, and benzo-15-crown-5 in DMF at 105-110?for 6 h gave 84% ether I (R = MeO).

Key words: REACTION MECHANISM, SUBSTITUTION REACTION, CROWN ETHER COMPOUNDS, IODIDE, DMF, ESTRADIOL, COPPER COMPOUNDS, NUCLEOPHILIC REACTION

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