Synthesis and Biological Activity of 2-(3-Phenoxymethyl-4- phenyl-[1,2,4]triazole-5-thio)acetic Acid

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (2): 343-347. Previous Articles Next Articles

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2-(3-芳氧甲基-4-苯基-1,2,4-三唑-5-硫基)乙酸的微波合成及生物活性研究

王良成，唐静，魏太保，张有明*

(西北师范大学化学化工学院甘肃省高分子重点实验室兰州 730070)

收稿日期:2007-06-07 修回日期:2007-08-17 发布日期:2008-02-01
通讯作者: 张有明

Synthesis and Biological Activity of 2-(3-Phenoxymethyl-4- phenyl-[1,2,4]triazole-5-thio)acetic Acid

WANG Liang-Cheng,TANG Jing,WEI Tai-Bao,ZHANG You-Ming*

(Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering,
Northwest Normal University, Lanzhou 730070)

Received:2007-06-07 Revised:2007-08-17 Published:2008-02-01
Contact: ZHANG You-Ming

Abstract

Six derivatives of 4-phenyl-3-phenoloxymethyl-5-mercapto-1,2,4-triazlyole were synthesized from phenoloxyacetyl hydrazide by two-steps reaction under microwave irradiation, then reacted with 2-chloroacetic acid to give six novel derivatives of 2-(3-phenoxymethyl-4-phenyl-[1,2,4]triazole-5-thio)- acetic acid. All the products were characterized by elemental analysis, FT-IR and ¹H NMR spectra. The preliminary biological activity tests showed that all the compounds have obvious regulating activities for the growth of cole.

Key words: biology activity, 2-(3-phenoxymethyl-4-phenyl-[1,2,4]triazole-5-thio)acetic acid, microwave irradiation, triazole

Cite this article

WANG Liang-Cheng,TANG Jing,WEI Tai-Bao,ZHANG You-Ming*. Synthesis and Biological Activity of 2-(3-Phenoxymethyl-4- phenyl-[1,2,4]triazole-5-thio)acetic Acid[J]. Chin. J. Org. Chem., 2008, 28(2): 343-347.

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2-(3-芳氧甲基-4-苯基-1,2,4-三唑-5-硫基)乙酸的微波合成及生物活性研究

Synthesis and Biological Activity of 2-(3-Phenoxymethyl-4- phenyl-[1,2,4]triazole-5-thio)acetic Acid

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